What may constrain the success of indoleamine 2,3-dioxygenase 1 inhibitors in cancer immunotherapy?
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Eleftheriadis T., Pissas G., Golfinopoulos S., Liakopoulos V., Stefanidis I. (2021)The present study evaluated indoleamine 2,3-dioxy- genase 1 (IDO) kinetics and how it affects cell survival during the two distinct phases of ischemia-reperfusion (I-R) injury. Primary renal proximal tubular epithelial ... -
Indoleamine 2,3-dioxygenase downregulates T-cell receptor complex ζ-chain and c-Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T-cells
Eleftheriadis T., Pissas G., Antoniadi G., Tsogka K., Sounidaki M., Liakopoulos V., Stefanidis I. (2016)Indoleamine 2,3-dioxygenase (IDO), through L-tryptophan depletion, activates general control non-derepressible (GCN) 2 kinase and suppresses T-cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, ... -
The role of indoleamine 2,3-dioxygenase in renal tubular epithelial cells senescence under anoxia or reoxygenation
Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ...