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What may constrain the success of indoleamine 2,3-dioxygenase 1 inhibitors in cancer immunotherapy?

Thumbnail
Auteur
Eleftheriadis T.
Date
2018
Language
en
DOI
10.3389/fimmu.2018.01879
Sujet
carnitine palmitoyltransferase I
cytotoxic T lymphocyte antigen 4
epacadostat
glucose transporter 1
indoleamine 2,3 dioxygenase
indoleamine 2,3 dioxygenase 1
indoleamine 2,3 dioxygenase 1 inhibitor
kynurenine
mammalian target of rapamycin complex 1
oxygenase inhibitor
pembrolizumab
protein p53
tryptophan
unclassified drug
antineoplastic agent
aromatic hydrocarbon receptor
EIF2AK4 protein, human
indoleamine 2,3 dioxygenase
protein serine threonine kinase
tryptophan
cancer immunotherapy
drug efficacy
enzyme activity
human
immune response
immunosurveillance
liver cell carcinoma
lymphocytic infiltration
metastatic melanoma
Note
protein expression
tumor growth
tumor microenvironment
immunological tolerance
immunology
immunomodulation
immunotherapy
metabolism
neoplasm
procedures
signal transduction
T lymphocyte
Antineoplastic Agents
Humans
Immune Tolerance
Immunomodulation
Immunotherapy
Indoleamine-Pyrrole 2,3,-Dioxygenase
Neoplasms
Protein-Serine-Threonine Kinases
Receptors, Aryl Hydrocarbon
Signal Transduction
T-Lymphocytes
Tryptophan
Frontiers Media S.A.
Afficher la notice complète
Résumé
[No abstract available]
URI
http://hdl.handle.net/11615/71307
Collections
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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  • Thumbnail

    Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells 

    Eleftheriadis T., Pissas G., Golfinopoulos S., Liakopoulos V., Stefanidis I. (2021)
    The present study evaluated indoleamine 2,3-dioxy- genase 1 (IDO) kinetics and how it affects cell survival during the two distinct phases of ischemia-reperfusion (I-R) injury. Primary renal proximal tubular epithelial ...
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    Indoleamine 2,3-dioxygenase downregulates T-cell receptor complex ζ-chain and c-Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T-cells 

    Eleftheriadis T., Pissas G., Antoniadi G., Tsogka K., Sounidaki M., Liakopoulos V., Stefanidis I. (2016)
    Indoleamine 2,3-dioxygenase (IDO), through L-tryptophan depletion, activates general control non-derepressible (GCN) 2 kinase and suppresses T-cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, ...
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    Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)
    Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ...
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