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What may constrain the success of indoleamine 2,3-dioxygenase 1 inhibitors in cancer immunotherapy?

Thumbnail
Autor
Eleftheriadis T.
Datum
2018
Language
en
DOI
10.3389/fimmu.2018.01879
Schlagwort
carnitine palmitoyltransferase I
cytotoxic T lymphocyte antigen 4
epacadostat
glucose transporter 1
indoleamine 2,3 dioxygenase
indoleamine 2,3 dioxygenase 1
indoleamine 2,3 dioxygenase 1 inhibitor
kynurenine
mammalian target of rapamycin complex 1
oxygenase inhibitor
pembrolizumab
protein p53
tryptophan
unclassified drug
antineoplastic agent
aromatic hydrocarbon receptor
EIF2AK4 protein, human
indoleamine 2,3 dioxygenase
protein serine threonine kinase
tryptophan
cancer immunotherapy
drug efficacy
enzyme activity
human
immune response
immunosurveillance
liver cell carcinoma
lymphocytic infiltration
metastatic melanoma
Note
protein expression
tumor growth
tumor microenvironment
immunological tolerance
immunology
immunomodulation
immunotherapy
metabolism
neoplasm
procedures
signal transduction
T lymphocyte
Antineoplastic Agents
Humans
Immune Tolerance
Immunomodulation
Immunotherapy
Indoleamine-Pyrrole 2,3,-Dioxygenase
Neoplasms
Protein-Serine-Threonine Kinases
Receptors, Aryl Hydrocarbon
Signal Transduction
T-Lymphocytes
Tryptophan
Frontiers Media S.A.
Zur Langanzeige
Zusammenfassung
[No abstract available]
URI
http://hdl.handle.net/11615/71307
Collections
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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    Eleftheriadis T., Pissas G., Antoniadi G., Tsogka K., Sounidaki M., Liakopoulos V., Stefanidis I. (2016)
    Indoleamine 2,3-dioxygenase (IDO), through L-tryptophan depletion, activates general control non-derepressible (GCN) 2 kinase and suppresses T-cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, ...
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    Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)
    Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ...
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