Objective and Subjective Appetite Assessment in Patients with Gynecological Cancer: A Pre- and Post-Operative Pilot Study
Date
2022Language
en
Keyword
Abstract
Although appetite and its disorders have been implicated in disease progression and outcomes, ghrelin concentrations, an objective appetite measure, are rarely assessed in patients with gynecological malignancies. The present study aimed to assess changes in post-operative versus pre-operative appetite levels in patients with gynecological cancers scheduled for tumor removal surgery (N = 53). Acylated ghrelin concentrations were assessed as an objective appetite proxy, whereas the Council of Nutrition appetite questionnaire (CNAQ) was employed as a subjective appetite measure. Ghrelin concentrations were increased post-operatively (median: 12.1 pg/mL, IQR: 0.67 to 23.5, p-value = 0.001) but the perceived appetite of patients (CNAQ) remained unchanged (median: −1, IQR: −3 to 1). Tumor removal surgery decreased all anthropometric indices (body weight, body mass index, waist and hips circumferences, triceps skinfolds, body fat, fat mass and fat mass index, p-value ≤ 0.001 for all) and doubled the risk of malnutrition among patients. No difference was recorded in the change in participants’ objective and subjective appetite when they were classified according to the tumor type. No correlation was observed between ghrelin concentrations and CNAQ score pre-operatively (Spearman’s rho correlation coefficient = −0.181, p-value = 0.298) or post-operatively (Spearman’s rho correlation coefficient = 0.071, p-value = 0.684). The observed post-operative rise in ghrelin concentrations is associated with body weight loss and consists of a possible defense mechanism of the human body, aiming to prolong survival. © 2022 by the authors.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Evaluating Alternative Ramucirumab Doses as a Single Agent or with Paclitaxel in Second-Line Treatment of Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma: Results from Two Randomized, Open-Label, Phase II Studies
Shah M.A., Udrea A.A., Bondarenko I., Mansoor W., Sánchez R.G., Sarosiek T., Bozzarelli S., Schenker M., Gomez-Martin C., Morgan C., Özgüroğlu M., Pikiel J., Kalofonos H.P., Wojcik E., Buchler T., Swinson D., Cicin I., Joseph M., Vynnychenko I., Luft A.V., Enzinger P.C., Salek T., Papandreou C., Tournigand C., Maiello E., Wei R., Ferry D., Gao L., Oliveira J.M., Ajani J.A. (2022)Studies JVDB and JVCZ examined alternative ramucirumab dosing regimens as monotherapy or combined with paclitaxel, respectively, in patients with advanced/metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. ... -
Appetite control across the lifecourse: The acute impact of breakfast drink quantity and protein content. the full4health project
Crabtree D.R., Buosi W., Fyfe C.L., Horgan G.W., Manios Y., Androutsos O., Giannopoulou A., Finlayson G., Beaulieu K., Meek C.L., Holst J.J., Van Norren K., Mercer J.G., Johnstone A.M., Full4Health-Study Group (2020)Understanding the mechanisms of hunger, satiety and how nutrients affect appetite control is important for successful weight management across the lifecourse. The primary aim of this study was to describe acute appetite ... -
Simulating real-life exposures to uncover possible risks to human health: A proposed consensus for a novel methodological approach
Tsatsakis A.M., Kouretas D., Tzatzarakis M.N., Stivaktakis P., Tsarouhas K., Golokhvast K.S., Rakitskii V.N., Tutelyan V.A., Hernandez A.F., Rezaee R., Chung G., Fenga C., Engin A.B., Neagu M., Arsene A.L., Docea A.O., Gofita E., Calina D., Taitzoglou I., Liesivuori J., Hayes A.W., Gutnikov S., Tsitsimpikou C. (2017)In real life, consumers are exposed to complex mixtures of chemicals via food, water and commercial products consumption. Since risk assessment usually focuses on individual compounds, the current regulatory approach doesn't ...