Prediction of particle deposition in the lungs based on simple modeling of alveolar mixing

Abstract

A simplified model of particle deposition in the lungs has been developed and implemented, based on the hypothesis that perfect mixing takes place in the alveolar volume of each airway generation. This key idea is combined with purely convective transport along airways, driven by steady alveolar expansion and contraction, and results in an analytically tractable model. Predictions of the model, and in particular pulmonary deposition, are found in very good agreement with detailed benchmark data in the literature for particle diameters d≥. 0.1 μm. The success of this simple model provides indirect evidence in favor of the role of alveolar mixing in the deposition process. © 2016 Elsevier B.V.