SLC2A3 rs12842 polymorphism and risk for Alzheimer’s disease
Data
2020Language
en
Soggetto
Abstract
Background: Many studies support the hypothesis that brain glucose dysregulation contributes to neurodegeneration and disease progression. The SLC2A3 gene encodes the Neuronal Glucose Transporter 3 (GLUT3), a critical molecule for glucose transport into the neuron. The GLUT3 rs12842 polymorphism has been associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD). Epidemiological and genetic studies have reported a link between antecedent ADHD and Alzheimer’s disease (AD), as both share a dysregulation of brain glucose. Aim: This study aimed to explore the possible correlation of the SLC2A3 rs12842 polymorphism with susceptibility towards AD. Methods: We genotyped 327 patients with AD and 327 controls for the GLUT3 rs12842. Results: Rs12842 was associated with a decreased risk of developing AD in the co-dominant [Odds Ratio (OR) (95% confidence interval (CI) = 0.67 (0.45–0.99)), p = 0.039], dominant [OR (95% CI) = 0.64 (0.44–0.93), p = 0.019] and log-additive modes [OR (95% CI) = 0.65 (0.46–0.91), p = 0.012]. Conclusions: Our results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study
Amorim T., Durães C., Machado J.C., Metsios G.S., Wyon M., Maia J., Flouris A.D., Marques F., Nogueira L., Adubeiro N., Koutedakis Y. (2018)Summary: The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are ... -
Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants
Dardiotis E., Siokas V., Sokratous M., Tsouris Z., Michalopoulou A., Andravizou A., Dastamani M., Ralli S., Vinceti M., Tsatsakis A., Hadjigeorgiou G.M. (2018)Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease of the central nervous system, characterized by progressive loss of motor neurons, and occurring in both sporadic and familial form. The origin of ... -
VDR Gene Polymorphisms and Cluster Headache Susceptibility: Case–Control Study in a Southeastern European Caucasian Population
Papasavva M., Vikelis M., Siokas V., Katsarou M.-S., Dermitzakis E., Raptis A., Dardiotis E., Drakoulis N. (2022)Cluster headache (CH) is a severe primary headache disorder with a genetic component, as indicated by family and twin studies. Diurnal and seasonal rhythmicity are key features of the disease and might be related to vitamin ...