dc.creator | Arseniou S., Siokas V., Aloizou A.-M., Stamati P., Mentis A.-F.A., Tsouris Z., Dastamani M., Peristeri E., Valotassiou V., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. | en |
dc.date.accessioned | 2023-01-31T07:33:14Z | |
dc.date.available | 2023-01-31T07:33:14Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1080/01616412.2020.1786973 | |
dc.identifier.issn | 01616412 | |
dc.identifier.uri | http://hdl.handle.net/11615/70817 | |
dc.description.abstract | Background: Many studies support the hypothesis that brain glucose dysregulation contributes to neurodegeneration and disease progression. The SLC2A3 gene encodes the Neuronal Glucose Transporter 3 (GLUT3), a critical molecule for glucose transport into the neuron. The GLUT3 rs12842 polymorphism has been associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD). Epidemiological and genetic studies have reported a link between antecedent ADHD and Alzheimer’s disease (AD), as both share a dysregulation of brain glucose. Aim: This study aimed to explore the possible correlation of the SLC2A3 rs12842 polymorphism with susceptibility towards AD. Methods: We genotyped 327 patients with AD and 327 controls for the GLUT3 rs12842. Results: Rs12842 was associated with a decreased risk of developing AD in the co-dominant [Odds Ratio (OR) (95% confidence interval (CI) = 0.67 (0.45–0.99)), p = 0.039], dominant [OR (95% CI) = 0.64 (0.44–0.93), p = 0.019] and log-additive modes [OR (95% CI) = 0.65 (0.46–0.91), p = 0.012]. Conclusions: Our results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. | en |
dc.language.iso | en | en |
dc.source | Neurological Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087756777&doi=10.1080%2f01616412.2020.1786973&partnerID=40&md5=7ab9b2eca169c55fcbab23a908278700 | |
dc.subject | genomic DNA | en |
dc.subject | glucose transporter 3 | en |
dc.subject | microRNA | en |
dc.subject | tau protein | en |
dc.subject | glucose transporter 3 | en |
dc.subject | SLC2A3 protein, human | en |
dc.subject | aged | en |
dc.subject | Alzheimer disease | en |
dc.subject | Article | en |
dc.subject | attention deficit disorder | en |
dc.subject | autism | en |
dc.subject | brain perfusion | en |
dc.subject | case control study | en |
dc.subject | cognition | en |
dc.subject | depression | en |
dc.subject | disease exacerbation | en |
dc.subject | DNA isolation | en |
dc.subject | DSM-IV | en |
dc.subject | executive function | en |
dc.subject | female | en |
dc.subject | gene | en |
dc.subject | gene frequency | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetic risk | en |
dc.subject | genotype | en |
dc.subject | hippocampus | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | Mini Mental State Examination | en |
dc.subject | nuclear magnetic resonance imaging | en |
dc.subject | prevalence | en |
dc.subject | risk factor | en |
dc.subject | Sanger sequencing | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | single photon emission computed tomography | en |
dc.subject | Alzheimer disease | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | odds ratio | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | very elderly | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Alzheimer Disease | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Glucose Transporter Type 3 | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Odds Ratio | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Taylor and Francis Ltd. | en |
dc.title | SLC2A3 rs12842 polymorphism and risk for Alzheimer’s disease | en |
dc.type | journalArticle | en |