Hypoventilation disproportionate to OSAS severity in children with Prader-Willi syndrome
Data
2019Language
en
Soggetto
Abstract
Objective To test the hypothesis that children with Prader-Willi syndrome (PWS) and obstructive sleep apnoea syndrome (OSAS) have hypercapnia for higher proportion of total sleep time (TST) than non-syndromic children with similar obstructive apnoea-hypopnoea index (OAHI). Design Cross-sectional study. Setting Two tertiary care hospitals. Patients Patients with PWS and non-syndromic children with snoring who underwent polygraphy and were of similar age, body mass index (BMI) z-score and OAHI. Main outcome measure The two groups were compared regarding %TST with transcutaneous CO 2 (PtcCO 2) >50 mm Hg. The interaction between PWS diagnosis and OSAS severity (OAHI <1 episode/h vs 1-5 episodes/h vs >5 episodes/h) regarding %TST with PtcCO 2 >50 mm Hg was tested using multiple linear regression. Results 48 children with PWS and 92 controls were included (median age 2.3 (range 0.2-14.1) years vs 2.2 (0.3-15.1) years; BMI z-score 0.7±1.9 vs 0.8±1.7; median OAHI 0.5 (0-29.5) episodes/h vs 0.5 (0-33.9) episodes/h; p>0.05). The two groups did not differ in %TST with PtcCO 2 >50 mm Hg (median 0% (0-100%) vs 0% (0-81.3%), respectively; p>0.05). However, the interaction between PWS and OSAS severity with respect to duration of hypoventilation was significant (p<0.01); the estimated mean differences of %TST with PtcCO 2 >50 mm Hg between children with PWS and controls for OAHI <1 episode/h, 1-5 episodes/h and >5 episodes/h were +0.2%, +1% and +33%, respectively. Conclusion Increasing severity of upper airway obstruction during sleep in children with PWS is accompanied by disproportionately longer periods of hypoventilation when compared with non-syndromic children with similar frequency of obstructive events. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Real-world clinical outcomes of treatment with brodalumab in patients with moderate-to-severe psoriasis: a retrospective, 24-month experience from four academic dermatology centers in Greece
Papadavid E., Zafeiriou E., Georgiou S., Roussaki-Schulze A.-V., Spiliopoulos T., Vryzaki E., Oikonomou C., Drongoula O., Boziou M., Goudouras G., Sfaelos K., Apalla Z., Lazaridou E. (2022)Objective: To assess the real-world clinical treatment outcomes with brodalumab in patients with moderate-to-severe plaque psoriasis in Greece. Materials and methods: This was a longitudinal, retrospective, real-world ... -
The use of cardiopulmonary exercise testing in identifying the presence of obstructive sleep apnea syndrome in patients with compatible symptomatology
Stavrou V., Boutou A.K., Vavougios G.D., Pastaka C., Gourgoulianis K.I., Koutedakis Y., Daniil Z., Karetsi E. (2019)The aim of this study was to investigate the relationship between cardiopulmonary exercise testing (CPET) and the presence of obstructive sleep apnea syndrome (OSAS) in order to provide an innovative tool to identify ... -
Porting disk-based spatial index structures to flash-based solid state drives
Carniel A.C., Roumelis G., Ciferri R.R., Vassilakopoulos M., Corral A., Aguiar C.D. (2022)Indexing data on flash-based Solid State Drives (SSDs) is an important paradigm recently applied in spatial data management. During last years, the design of new spatial access methods for SSDs, named flash-aware spatial ...