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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis

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Author
Stefanidis, I.; Giannopoulou, M.; Liakopoulos, V.; Dovas, S.; Karasavvidou, F.; Zachou, K.; Koukoulis, G. K.; Dalekos, G. N.
Date
2008
Keyword
Autoimmune hepatitis
Membranous nephropathy
Sjögren syndrome
alanine aminotransferase
albumin
antinuclear antibody
aspartate aminotransferase
autoantibody
calcium
cholesterol
creatine kinase
cyclophosphamide
cyclosporin
enoxaparin
estrogen
immunoglobulin A
immunoglobulin G
immunoglobulin M
irbesartan
methylprednisolone
mycophenolic acid 2 morpholinoethyl ester
perindopril
prednisolone
progesterone
ribonucleoprotein antibody
Ro antibody
simvastatin
triacylglycerol
vitamin
adult
alanine aminotransferase blood level
anemia
ankle edema
antibody production
antibody titer
antigen antibody complex
article
aspartate aminotransferase blood level
autoimmune disease
autoimmunity
B lymphocyte
case report
clinical feature
comorbidity
diet supplementation
disease association
drug dose reduction
drug substitution
drug withdrawal
erythrocyte sedimentation rate
exocrine gland
female
hematocrit
histopathology
hospital admission
human
hypercholesterolemia
hypergammaglobulinemia
hypertriglyceridemia
hypoalbuminemia
immune complex deposition
interstitial nephritis
kidney biopsy
lacrimal gland
liver biopsy
liver fibrosis
liver function test
lymphocytic infiltration
membranous glomerulonephritis
muscle biopsy
muscle weakness
myopathy
pathophysiology
physical examination
polymyositis
primary biliary cirrhosis
proteinuria
remission
salivary gland
side effect
Sjoegren syndrome
skin biopsy
treatment outcome
tubular dysfunction
urinalysis
Glomerulonephritis, Membranous
Hepatitis, Autoimmune
Humans
Sjogren's Syndrome
Metadata display
Abstract
Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell hyperactivity, which results in production of autoantibodies and immune complexes. SS can exist as a primary disorder or in association with other autoimmune processes. A usually mild, proximal and insidious inflammatory myopathy can occur in patients with SS with a broad clinical and pathological spectrum. Interstitial nephritis with mild proteinuria and tubular dysfunction is the most common renal manifestation of SS, but glomerular involvement due to immune complex deposition may also rarely occur [Goules et al. 2000]. There is an association of SS with hepatic abnormalities, as evidenced by abnormal liver biochemical tests or histological characteristics of primary biliary cirrhosis (PBC), portal tract fibrosis, or autoimmune hepatitis [Abraham et al. 2004]. The pathogenetic mechanism of liver involvement in SS is not clear, but it is possible that hepatic and salivary gland damage share a similar pathology. The combination of Sjögren syndrome with kidney, liver and muscle involvement in one entity is extremely rare and data in the literature are remarkably sparse. We present a case of a 43-year-old female patient suffering from SS accompanied by polymyositis, membranous nephropathy and autoimmune hepatitis. ©2008 Dustri-Verlag Dr. K. Feistle.
URI
http://hdl.handle.net/11615/33416
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [9728]

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