Browsing by Subject "remission"

(2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease

Manolakis A.C., Christodoulidis G., Kapsoritakis A.N., Georgoulias P., Tiaka E.K., Oikonomou K., Valotassiou V.J., Potamianos S.P. (2017)

AIM: To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein (AHSG/fetuin A) and potential associations with disease and patient characteristics. METHODS: AHSG serum levels were ...

Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis

Zachou K., Arvaniti P., Lyberopoulou A., Sevdali E., Speletas M., Ioannou M., Koukoulis G.K., Renaudineau Y., Dalekos G.N. (2022)

Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ...

Autoantibodies against specific nuclear antigens are present in psoriatic disease and are diminished by secukinumab

Patrikiou E., Liaskos C., Mavropoulos A., Ntavari N., Gkoutzourelas A., Simopoulou T., Fechner K., Scheper T., Meyer W., Katsiari C.G., Roussaki-Schulze A., Zafiriou E., Sakkas L.I., Bogdanos D.P. (2020)

Anti-nuclear antibodies (ANA) are frequently detected in patients with psoriasis (Ps) and psoriatic arthritis (PsA), but their target autoantigens remain unknown. We assessed antibody (ab) reactivity against 23 known nuclear ...

Autoimmune hepatitis in patients with multiple sclerosis: The role of immunomodulatory treatment

Rigopoulou E.I., Gyftaki S., Arvaniti P., Tsimourtou V., Koukoulis G.K., Hadjigeorgiou G., Dalekos G.N. (2019)

Background: Development of autoimmune hepatitis (AIH) has been sporadically reported in patients with multiple sclerosis (MS) either concurrently or after treatment with immunomodulatory drugs, including interferon-beta ...

Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: Art of facts or an artifact?

Zellos, A.; Spoulou, V.; Roma-Giannikou, E.; Karentzou, O.; Dalekos, G. N.; Theodoridou, M. (2013)

Epstein-Barr virus (EBV) can cause frequently asymptomatic (or anicteric) and self-limited hepatitis, while occasionally may result in considerable cholestatic hepatitis. Herein, we describe the case of a previously healthy ...

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis

Arvaniti P., Giannoulis G., Gabeta S., Zachou K., Koukoulis G.K., Dalekos G.N. (2020)

Background & Aims: Autoimmune hepatitis (AIH) is a disease of unknown aetiology with a favourable response to immunosuppression. However, in the clinic, it appears that <50% of patients achieve complete response on standard ...

Black holes and high levels of neurofilaments in glial fibrillary acidic protein – astrocytopathy: a case report

Papa A., Tzartos J.S., Sakoutis G., Dardiotis E., Alexiou E., Breza M., Velonakis G., Papamichalis P., Mpampalis D., Komnos A., Karagiorgou A., Papakonstantinou A., Kilidireas C., Hadjigeorgiou G.M. (2020)

Background and purpose: Glial fibrillary acidic protein (GFAP) is an intracellular protein of the astrocytic cytoskeleton. Recently, autoantibodies to GFAP detected by cell-based assay in cerebrospinal fluid (CSF) or serum ...

A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis

Stefanidis, I.; Giannopoulou, M.; Liakopoulos, V.; Dovas, S.; Karasavvidou, F.; Zachou, K.; Koukoulis, G. K.; Dalekos, G. N. (2008)

Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell ...

Checkpoint modulation in chronic hepatitis B: From hypothesis to approval

Germanidis G., Hytiroglou P., Vassiliadis T., Speletas M. (2018)

[No abstract available]

Clinical, functional and radiographic outcomes after revision total hip arthroplasty with tapered fluted modular or non-modular stems: a systematic review

Koutalos A.A., Varitimidis S., Malizos K.N., Karachalios T. (2022)

Purpose: The aim of the study was to systematically evaluate clinical outcomes of tapered fluted stems, either monoblock or modular, in revision total hip arthroplasty. Methods: PubMed, EMBASE and Web of Science and Cochrane ...

Common and Uncommon Artifacts in T1 FLAIR SAG Sequences of MRI Brain

Lavdas E., Papaioannou M., Boci N., Dardiotis E., Roka V., Sakkas G.K., Apostolopoulou G., Gogou L., Mavroidis P. (2021)

Objective: This study aims at identifying, classifying, and measuring the frequency the different artifacts that show up in the images of the Sagittal T1 Fluid Attenuated Inversion Recovery (FLAIR) sequence. Materials and ...

CpG Island Methylation Patterns in Relapsing-Remitting Multiple Sclerosis

Sokratous M., Dardiotis E., Bellou E., Tsouris Z., Michalopoulou A., Dardioti M., Siokas V., Rikos D., Tsatsakis A., Kovatsi L., Bogdanos D.P., Hadjigeorgiou G.M. (2018)

DNA methylation may predispose to multiple sclerosis (MS), as aberrant methylation in the promoter regions across the genome seems to underlie several processes of MS. We have currently determined the methylation status ...

Daptomycin Use in Children: Experience with Various Types of Infection and Age Groups

Syrogiannopoulos G.A., Michoula A.N., Petinaki E., Grivea I.N. (2017)

Background: In Greece, there are high rates of methicillin (40%-60%) and clindamycin (15%-25%) resistance among community-acquired Staphylococcus aureus isolates. Therefore, we sought to identify other antimicrobial treatment ...

Daring-B: Discontinuation of effective entecavir or tenofovir disoproxil fumarate long-term therapy before HBsAg loss in non-cirrhotic HBeAg-negative chronic hepatitis B

Papatheodoridis G.V., Rigopoulou E.I., Papatheodoridi M., Zachou K., Xourafas V., Gatselis N., Hadziyannis E., Vlachogiannakos J., Manolakopoulos S., Dalekos G.N. (2018)

Background: The remission rates after stopping antivirals in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) vary among studies, while reliable predictors of relapse have not been identified. This prospective ...

Decreased serum DNase1-activity in patients with autoimmune liver diseases

Gatselis N.K., Vakrakou A.G., Zachou K., Androutsakos T., Azariadis K., Hatzis G., Manoussakis M.N., Dalekos G.N. (2017)

Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first ...

Editorial: Autoimmune hepatitis - Identifying options for treatment. Authors' reply

Dalekos G.N., Zachou K. (2016)

[No abstract available]

Efficacy and Safety Profile of Anti-tumor Necrosis Factor-α Versus Anti-integrin Agents for the Treatment of Crohn's Disease: A Network Meta-analysis of Indirect Comparisons

Miligkos M., Papamichael K., Casteele N.V., Mantzaris G.J., Gils A., Levesque B.G., Zintzaras E. (2016)

Purpose To compare the benefits and harms of anti-tumor necrosis factor (TNF)-α and anti-integrin agents as induction and maintenance therapy in adult patients with Crohn's disease. Methods We searched MEDLINE and the ...