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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis

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Author
Ruhwald, M.; Dominguez, J.; Latorre, I.; Losi, M.; Richeldi, L.; Pasticci, M. B.; Mazzolla, R.; Goletti, D.; Butera, O.; Bruchfeld, J.; Gaines, H.; Gerogianni, I.; Tuuminen, T.; Ferrara, G.; Eugen-Olsen, J.; Ravn, P.
Date
2011
DOI
10.1016/j.tube.2011.01.001
Keyword
ESAT-6 protein
Interferon-gamma
M. tuberculosis
Mitogen
gamma interferon
gamma interferon inducible protein 10
adult
aged
algorithm
article
blood
clinical article
comorbidity
controlled study
diagnostic accuracy
diagnostic test
extrapulmonary tuberculosis
female
human
lung tuberculosis
male
Mycobacterium tuberculosis
outcome assessment
priority journal
QuantiFERON TB Gold In Tube test
risk factor
sensitivity and specificity
task performance
Adolescent
Aged, 80 and over
Algorithms
Biological Markers
Chemokine CXCL10
Denmark
Humans
Italy
Middle Aged
Spain
Tuberculin Test
Tuberculosis
Young Adult
Metadata display
Abstract
IP-10 has potential as a diagnostic marker for infection with Mycobacterium tuberculosis, with comparable accuracy to QuantiFERON-TB Gold In-Tube test (QFT-IT). The aims were to assess the sensitivity and specificity of IP-10, and to evaluate the impact of co-morbidity on IP-10 and QFT-IT. 168 cases with active TB, 101 healthy controls and 175 non-TB patients were included. IP-10 and IFN-γ were measured in plasma of QFT-IT stimulated whole blood and analyzed using previously determined algorithms. A subgroup of 48 patients and 70 healthy controls was tested in parallel with T-SPOT.TB IP-10 and QFT-IT had comparable accuracy. Sensitivity was 81% and 84% with a specificity of 97% and 100%, respectively. Combining IP-10 and QFT-IT improved sensitivity to 87% (p < 0.0005), with a specificity of 97%. T-SPOT.TB was more sensitive than QFT-IT, but not IP-10. Among non-TB patients IP-10 had a higher rate of positive responders (35% vs 27%, p < 0.02) and for both tests a positive response was associated with relevant risk factors. IFN-γ but not IP-10 responses to mitogen stimulation were reduced in patients with TB and non-TB infection. This study confirms and validates previous findings and adds substance to IP-10 as a novel diagnostic marker for infection with M. tuberculosis. IP-10 appeared less influenced by infections other than TB; further studies are needed to test the clinical impact of these findings. © 2011 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/11615/32734
Collections
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [9714]

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