A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis
dc.creator | Ruhwald, M. | en |
dc.creator | Dominguez, J. | en |
dc.creator | Latorre, I. | en |
dc.creator | Losi, M. | en |
dc.creator | Richeldi, L. | en |
dc.creator | Pasticci, M. B. | en |
dc.creator | Mazzolla, R. | en |
dc.creator | Goletti, D. | en |
dc.creator | Butera, O. | en |
dc.creator | Bruchfeld, J. | en |
dc.creator | Gaines, H. | en |
dc.creator | Gerogianni, I. | en |
dc.creator | Tuuminen, T. | en |
dc.creator | Ferrara, G. | en |
dc.creator | Eugen-Olsen, J. | en |
dc.creator | Ravn, P. | en |
dc.date.accessioned | 2015-11-23T10:46:41Z | |
dc.date.available | 2015-11-23T10:46:41Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1016/j.tube.2011.01.001 | |
dc.identifier.issn | 14729792 | |
dc.identifier.uri | http://hdl.handle.net/11615/32734 | |
dc.description.abstract | IP-10 has potential as a diagnostic marker for infection with Mycobacterium tuberculosis, with comparable accuracy to QuantiFERON-TB Gold In-Tube test (QFT-IT). The aims were to assess the sensitivity and specificity of IP-10, and to evaluate the impact of co-morbidity on IP-10 and QFT-IT. 168 cases with active TB, 101 healthy controls and 175 non-TB patients were included. IP-10 and IFN-γ were measured in plasma of QFT-IT stimulated whole blood and analyzed using previously determined algorithms. A subgroup of 48 patients and 70 healthy controls was tested in parallel with T-SPOT.TB IP-10 and QFT-IT had comparable accuracy. Sensitivity was 81% and 84% with a specificity of 97% and 100%, respectively. Combining IP-10 and QFT-IT improved sensitivity to 87% (p < 0.0005), with a specificity of 97%. T-SPOT.TB was more sensitive than QFT-IT, but not IP-10. Among non-TB patients IP-10 had a higher rate of positive responders (35% vs 27%, p < 0.02) and for both tests a positive response was associated with relevant risk factors. IFN-γ but not IP-10 responses to mitogen stimulation were reduced in patients with TB and non-TB infection. This study confirms and validates previous findings and adds substance to IP-10 as a novel diagnostic marker for infection with M. tuberculosis. IP-10 appeared less influenced by infections other than TB; further studies are needed to test the clinical impact of these findings. © 2011 Elsevier Ltd. All rights reserved. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-79955695160&partnerID=40&md5=48872fe84f8a9786a0fa370155f91fba | |
dc.subject | ESAT-6 protein | en |
dc.subject | Interferon-gamma | en |
dc.subject | M. tuberculosis | en |
dc.subject | Mitogen | en |
dc.subject | gamma interferon | en |
dc.subject | gamma interferon inducible protein 10 | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | algorithm | en |
dc.subject | article | en |
dc.subject | blood | en |
dc.subject | clinical article | en |
dc.subject | comorbidity | en |
dc.subject | controlled study | en |
dc.subject | diagnostic accuracy | en |
dc.subject | diagnostic test | en |
dc.subject | extrapulmonary tuberculosis | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | lung tuberculosis | en |
dc.subject | male | en |
dc.subject | Mycobacterium tuberculosis | en |
dc.subject | outcome assessment | en |
dc.subject | priority journal | en |
dc.subject | QuantiFERON TB Gold In Tube test | en |
dc.subject | risk factor | en |
dc.subject | sensitivity and specificity | en |
dc.subject | task performance | en |
dc.subject | Adolescent | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Algorithms | en |
dc.subject | Biological Markers | en |
dc.subject | Chemokine CXCL10 | en |
dc.subject | Denmark | en |
dc.subject | Humans | en |
dc.subject | Italy | en |
dc.subject | Middle Aged | en |
dc.subject | Spain | en |
dc.subject | Tuberculin Test | en |
dc.subject | Tuberculosis | en |
dc.subject | Young Adult | en |
dc.title | A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |