Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles
Ημερομηνία
2000Λέξη-κλειδί
Επιτομή
The objective of the study was to investigate the effect of endothelin-1 (ET-1) on KCl-induced contractions. Tracheal strips were obtained from 12 male rabbits, perfused with Krebs solution and aerated continuously by bubbling with a mixture of 95% O2-5% CO2. Increasing concentrations of ET-1 (10-12-10-7 M) additionally to KCl caused more contractions than KCl-induced (P<0.05). A total of 10-7 M ET-1-induced 14.56% more contraction. Methylene blue (10-5 M) decreased all the contractions induced from simultaneous use of KCl and ET-1. Methylene blue caused about 18% relaxation of contraction induced from KCl (80 mM) and ET-1 (10-8 M). Consequently ET-1 increases the KCl-induced contractions of airway smooth muscles. This effect seem to mediate by a nitric oxide (NO)-guanylate cyclase-cGMP pathway, in which methylene blue is inactivator of guanylate cyclase. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Collections
Related items
Showing items related by title, author, creator and subject.
-
The effects of training with high-speed interval running on muscle performance are modulated by slope
Theofilidis G., Bogdanis G.C., Stavropoulos-Kalinoglou A., Krase A.A., Tsatalas T., Shum G., Sakkas G.K., Koutedakis Y., Karatzaferi C. (2021)We examined changes in selected muscle performance parameters after 8 weeks of interval training using two opposite running inclinations. We hypothesized that the uphill training will affect endurance muscle performance ... -
Respiratory, cardiac and metabolic responses during electrical muscle stimulation in quadriceps muscle versus comparable voluntary muscle contractions
Kortianou E.A., Papafilippou E.K., Karagkounis A. (2021)Electrical Muscle Stimulation (EMS) and voluntary muscle contraction (VMC) are both acceptable rehabilitative modalities to preserve muscle strength loss. The study aimed to compare respiratory, metabolic, and cardiac ... -
The redox-dependent regulation of satellite cells following aseptic muscle trauma (SpEED): Study protocol for a randomized controlled trial
Papanikolaou K., Draganidis D., Chatzinikolaou A., Laschou V.C., Georgakouli K., Tsimeas P., Batrakoulis A., Deli C.K., Jamurtas A.Z., Fatouros I.G. (2019)Background: Muscle satellite cells (SCs) are crucial for muscle regeneration following muscle trauma. Acute skeletal muscle damage results in inflammation and the production of reactive oxygen species (ROS) which may be ...