Πλοήγηση ανά Θέμα "rabbit"
Αποτελέσματα 1-15 από 15
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Cardiotoxicity in rabbits after long-term nandrolone decanoate administration
(2016)Abuse of anabolic androgenic steroids is linked to a variety of cardiovascular complications. The aim of our study was to investigate the possible cardiovascular effects of nandrolone decanoate on young rabbits using ... -
Development and application of GC-MS method for monitoring of long-term exposure to the pesticide cypermethrin
(2014)Cypermethrin (CPMN) is a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as for domestic purposes. In the present study a gas chromatography-mass spectrometry (GC-MS) ... -
Downgrading the systemic condition of rabbits after long term exposure to cypermethrin and piperonyl butoxide
(2016)Aim The aim of this study is to clarify the effect of cypermethrin (CY) on the oxidative stress (OS) and inflammation status of animals exposed to it and the synergistic role of piperonyl butoxide (PB0). Main methods Markers ... -
Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles
(2000)The objective of the study was to investigate the effect of endothelin-1 (ET-1) on KCl-induced contractions. Tracheal strips were obtained from 12 male rabbits, perfused with Krebs solution and aerated continuously by ... -
Epithelium-dependent effect of L-glutamate on airways: involvement of prostaglandins
(2002)WE, investigated the effect of the excitatory amino acid (EAA) receptor agonists L-glutamate, N-methyl-D-aspartate (NMDA), (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainic acid on KCl-induced ... -
Epithelium-dependent regulation of airways smooth muscle function. A histamine-nitric oxide pathway
(1998)The airway epithelium is responsible for the production of a number of arachidonic acid and non-prostanoid inhibitory factors. Epithelium synthesizes nitric oxide (NO) which may be important in regulating the function of ... -
An evaluation of indirubin analogues as phosphorylase kinase inhibitors
(2015)Phosphorylase kinase (PhK) has been linked with a number of conditions such as glycogen storage diseases, psoriasis, type 2 diabetes and more recently, cancer (Camus et al., 2012 [6]). However, with few reported structural ... -
Glycogen phosphorylase as a target for type 2 diabetes: Synthetic, biochemical, structural and computational evaluation of novel N-acyl-N´-(β-D-glucopyranosyl) urea inhibitors
(2015)Glycogen phosphorylase (GP), a validated target for the development of anti-hyperglycaemic agents, has been targeted for the design of novel glycopyranosylamine inhibitors. Exploiting the two most potent inhibitors from ... -
Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells
(2007)Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ... -
Nephrotoxicity in rabbits after long-term nandrolone decanoate administration
(2016)Among the various side effects of supra-physiological dose of anabolic androgenic steroids that are described, renal toxicity remains the least evaluated. The present study provides evidence that long-term administration ... -
Non-genomic effect of testosterone on airway smooth muscle
(2006)Background and purpose: Recent studies on blood vessels have provided evidence that testosterone may exert direct effects on smooth muscle. However, an acute effect on airway reactivity has not been shown yet. The aim of ... -
Resting tension effect on airway smooth muscle: the involvement of epithelium
(2005)We studied the influence of resting tension (RT) on rabbit tracheal smooth muscle (TSM) contractions induced by acetylcholine or KCl as well as the role of epithelium and the endogenously produced nitric oxide, prostanoids ... -
The role of nitric oxide in the pathophysiology of bronchial asthma
(1998)OBJECTIVE: To study in vitro the role of nitric oxide (NO), in the pathophysiology of asthma observing the effections of a NO-donor such as sodium nitroprusside, a calcium (Ca) channel inhibitor nifedipine or neurotransmitter ... -
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase
(2016)C-β-D-Glucopyranosyl pyrrole derivatives were prepared in the reactions of pyrrole, 2-, and 3-aryl-pyrroles with O-peracetylated β-D-glucopyranosyl trichloroacetimidate, while 2-(β-D-glucopyranosyl) indole was obtained by ...