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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
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Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma

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Author
Abazis-Stamboulieh, D.; Oikonomou, P.; Papadoulis, N.; Panayiotidis, P.; Vrakidou, E.; Tsezou, A.
Date
2007
DOI
10.1080/10428190701615892
Keyword
interleukin-1
polymorphisms
multiple myeloma
SINGLE NUCLEOTIDE POLYMORPHISMS
NECROSIS-FACTOR-ALPHA
BONE-MARROW
CELLS
CYTOKINE POLYMORPHISMS
CANCER
STIMULATION
PROMOTER
SUSCEPTIBILITY
POPULATION
IL-1-BETA
Oncology
Hematology
Metadata display
Abstract
Interleukin-1 (IL-1) is a cytokine involved in the maturation and proliferation of B cells and plays a significant role in the development of lytic bone lesions, a major clinical feature of multiple myeloma (MM) patients. Genes that regulate products involved in the immune system are highly polymorphic and contribute to inter-individual differences that can influence the genetic predisposition and progression of particular diseases and cancers. In this study, we investigated the correlation between the single nucleotide polymorphisms IL1A -889, IL1B -511, IL1B +3954, IL1RN Mspa1 +11100 and susceptibility to MM in 74 patients and 160 controls. We found that individuals possessing IL1A -889 CT polymorphism had a higher risk in developing MM. Moreover, genotypes IL1B 7511 CC, IL1B +3954 CC, IL-1RN Mspa1 +11100 CC and the combination of IL 1B +3954 CC with IL1B 7511 CC or IL-1RN Mspa1 +11100 CC exerted a protective effect in individuals possessing them.
URI
http://hdl.handle.net/11615/25329
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19705]
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