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MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes
(2015)
Introduction: Several studies have shown that osteoarthritis (OA) is strongly associated with metabolism-related disorders, highlighting OA as the fifth component of the metabolic syndrome (MetS). On the basis of our ...
Protective Effect of Atorvastatin in Cultured Osteoarthritic Chondrocytes
(2010)
The aim of our study was to evaluate the in vitro effect of an HMG-CoA reductase inhibitor, atorvastatin, on the expression of significant anabolic and catabolic genes in human osteoarthritic chondrocytes and to explore ...
Trabecular metal - Orthopaedic applications of a novel material
(2011)
Unlike conventional porous-coated materials used in orthopaedic surgery, Trabecular Metal™ (TMT) is a novel material. It is made of tantalum with three-dimensional porosity throughout its volume resembling the structure ...
DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
(2015)
Introduction: Sclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes' hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is ...
Does Electric Stimulation of the Vastus Medialis Muscle Influence Rehabilitation After Total Knee Replacement?
(2011)
Patients with knee osteoarthritis present with reduced quadriceps muscle strength, which is partially responsible for impaired function and disability. Although total knee replacement (TKR) is an effective surgical procedure, ...
Expression profile of osteoprotegerin, RANK and RANKL genes in the femoral head of patients with avascular necrosis
(2014)
Introduction: Femoral head avascular necrosis (AVN) is a recalcitrant disease of the hip that leads to joint destruction. Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa-B (RANK) and RANK ligand (RANKL) ...
Repair and tissue engineering techniques for articular cartilage
(2015)
Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, eventually leading to progressive total joint destruction. Although current progress suggests that ...
Digital coverage with flaps from the same or neighboring digits
(2011)
Objective: Several flaps can be dissected from the same or neighboring digits for the reconstruction of relatively large soft tissue digital defects. Material and Methods: In a 6-year period, 106 large soft tissue digital ...
Finite element simulation of the mechanical impact of computer work on the carpal tunnel syndrome
(2014)
Carpal tunnel syndrome (CTS) is a clinical disorder resulting from the compression of the median nerve. The available evidence regarding the association between computer use and CTS is controversial. There is some evidence ...
I CAN! A graduate self-completion questionnaire for evaluating medical curriculum outcomes: How to use it, and preliminary findings on Greek medical education outcomes
(2011)
Objective Although valid instruments are available for measuring the educational environment during the 6-year period of undergraduate medical study, there was no tool for measuring the end-product of the medical curriculum, ...