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1,25-Dihydroxyvitamin D-3 and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytes
(2012)
Hypertrophy and impaired mineralization are two processes closely associated with osteoarthritis (OA). 1,25-dihydroxyvitamin D-3 (1a,25(OH)(2)D-3) and inorganic phosphate (Pi) are two important factors that are implicated ...
Bone morphogenetic protein-2-induced Wnt/beta-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes
(2012)
Introduction: Events normally taking place in the terminal chondrocyte differentiation in the growth plate are also observed during osteoarthritis (OA) development, suggesting that molecules, such as Wnts and bone morphogenetic ...
Predictive role of cytokine gene polymorphisms for the development of femoral head osteonecrosis
(2012)
Introduction: Osteonecrosis (ON) is a multifactorial disease that leads to hip destruction. Lately, much focus has been at femoral head preservation with nonsurgical methods. In this study we examined the polymorphisms of ...
Tourniquet Use Does Not Affect Rehabilitation, Return to Activities, and Muscle Damage After Arthroscopic Meniscectomy: A Prospective Randomized Clinical Study
(2012)
Purpose: The purpose of this prospective randomized trial was to examine the effect of tourniquet use on rehabilitation rate, return to work and sport activities, and muscle damage after arthroscopic meniscectomy. Methods: ...
Smoking affects mRNA expression of bone morphogenetic proteins in human periosteum
(2012)
Periosteum is important for bone homoeostasis through the release of bone morphogenetic proteins (BMPs) and their effect on osteoprogenitor cells. Smoking has an adverse effect on fracture healing and bone regeneration. ...
Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis
(2012)
Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ...
Factors affecting the quality of life after total knee arthroplasties: a prospective study
(2012)
Background: The purpose of the study is to evaluate the self-reported outcomes in the first year after primary total knee arthroplasty (TKA), and to determine factors influencing the quality of life (QoL) 6 weeks, 3, 6, ...
Early results of a novel technique using multiple small tantalum pegs for the treatment of osteonecrosis of the femoral head A CASE SERIES INVOLVING 26 HIPS
(2012)
The introduction of a trabecular tantalum rod has been proposed for the management of early-stage osteonecrosis of the femoral head but serves as a single-point of support of the necrotic lesion. We describe a technique ...
Effect of fatigue on tibial rotation after single- and double-bundle anterior cruciate ligament reconstruction: A 3-dimensional kinematic and kinetic matched-group analysis
(2012)
Background: Fatigue is an extrinsic factor adversely affecting joint proprioception and neuromuscular response, thereby increasing anterior cruciate ligament (ACL) strain and injury risk. The effectiveness of the single- ...
Cumulative keyboard strokes: a possible risk factor for carpal tunnel syndrome
(2012)
Background: Contradictory reports have been published regarding the association of Carpal Tunnel Syndrome (CTS) and the use of computer keyboard. Previous studies did not take into account the cumulative exposure to keyboard ...