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The s-Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

Kantsadi, A. L.; Hayes, J. M.; Manta, S.; Skamnaki, V. T.; Kiritsis, C.; Psarra, A. M. G.; Koutsogiannis, Z.; Dimopoulou, A.; Theofanous, S.; Nikoleousakos, N.; Zoumpoulakis, P.; Kontou, M.; Papadopoulos, G.; Zographos, S. E.; Komiotis, D.; Leonidas, D. D. (2012)

C5 halogen substituted glucopyranosyl nucleosides (1-(beta-D-glucopyranosyl)-5-X-uracil; X=Cl, Br, I) have been discovered as some of the most potent active site inhibitors of glycogen phosphorylase (GP), with respective ...

S.H.A.K.E. COVID-19

Vasileios M., Baxevanidou K., Aristeidis Z. (2021)

[No abstract available]

Sad3 and Sad4 are required for saponin biosynthesis and root development in oat

Mylona, P.; Owatworakit, A.; Papadopoulou, K.; Jenner, H.; Qin, B.; Findlay, K.; Hill, L.; Qi, X.; Bakht, S.; Melton, R.; Osbourn, A. (2008)

Avenacins are antimicrobial triterpene glycosides that are produced by oat (Avena) roots. These compounds confer broad-spectrum resistance to soil pathogens. Avenacin A-1, the major avenacin produced by oats, is strongly ...

Saddle Nose with Recurrent Sinusitis and Arthralgias: a Not-to-lose Diagnosis

Syrmou V., Simopoulou T., Bogdanos D.P., Alexiou I. (2022)

Nasal and lung features in a patient with Granulomatosis with Polyangiitis (GPA, formerly called Wegener’s). A 39-year-old man presented with a 6-month history of recurrent sinusitis, nose deformity (Figure 1A), low grade ...

The saddle point problem and the Manteuffel algorithm

Hadjidimos A. (2016)

In the last two decades, the augmented linear systems and the saddle point problems have been solved by many researchers who have used the conjugate gradient method or the generalized SOR iterative method and variants of ...

SAFB1 interacts with and suppresses the transcriptional activity of p53

Peidis, P.; Voukkalis, N.; Aggelidou, E.; Georgatsou, E.; Hadzopoulou-Cladaras, M.; Scott, R. E.; Nikolakaki, E.; Giannakouros, T. (2011)

A significant amount of nuclear p53 is found associated with the nuclear matrix in cells that were exposed to genotoxic stress. In this study we identified Scaffold attachment factor B1 (SAFB1), a nuclear matrix-associated ...

Safe Optimistic Path Planning for Autonomous Drones under Dynamic Energy Costs

Polychronis G., Lalis S. (2021)

Unmanned aerial vehicles or so-called drones are already used in several applications to perform different sensing and monitoring missions. A central problem is to plan these missions so as to minimize the completion time. ...

Safe Reinforcement Learning in Simulated Environment of Self-Driving Laboratory

Chernov A.V., Savvas I.K., Butakova M.A., Kartashov O.O. (2021)

Today we see tremendous potential in applying artificial intelligence (AI), deep reinforcement learning, and agent-based simulation to complex real-world problems. AI helps people support and automate decision-making ...

Safe use of chemicals by professional users and health care specialists

Apatsidou M., Konstantopoulou I., Foufa E., Tsarouhas K., Papalexis P., Rezaee R., Spandidos D.A., Kouretas D., Tsitsimpikou C. (2018)

The awareness of Greek professional users and health care specialists regarding the safe use of chemicals was investigated, to be the best of our knowledge, for the first time after the introduction of Regulations (EC) ...

Safeguarding the integrity of large-diameter steel pipelines subjected to differential ground settlements

Fappas D., Sarvanis G.C., Karamanos S.A., Keil B.D., Mielke R.D., Card R.J. (2021)

The paper describes the application of a novel and promising concept, aimed at absorbing ground-induced displacements due to soil subsidence in buried steel pipelines entering or exiting concrete or rigid structures. In ...

Safety and effectiveness of alveolar recruitment maneuvers and positive end-expiratory pressure during general anesthesia for cesarean section: a prospective, randomized trial Alveolar recruitment during caesarean section

Aretha D., Fligou F., Kiekkas P., Messini C., Panteli E., Zintzaras E., Karanikolas M. (2017)

Introduction During cesarean section, the supine position reduces functional residual capacity and worsens lung compliance. We tested the hypothesis that alveolar recruitment maneuvers and positive end-expiratory pressure ...

SAFETY AND EFFICACY OF 96 WEEKS OF TENOFOVIR DISOPROXIL FUMARATE THERAPY IN LAMIVUDINE EXPERIENCED PATIENTS

Manns, M.; Jeffers, L.; Dalekos, G.; Berg, T.; Trepo, C.; Roberts, S.; Prieto, M.; Rizzetto, M.; Marcellin, P.; Heathcote, E. J.; Sorbel, J.; Anderson, J.; Mondou, E.; Rousseau, F. (2009)

Safety and efficacy of lamivudine in patients with severe acute or fulminant hepatitis B, a multicenter experience

Tillmann, H. L.; Hadem, J.; Leifeld, L.; Zachou, K.; Canbay, A.; Eisenbach, C.; Graziadei, I.; Encke, J.; Schmidt, H.; Vogel, W.; Schneider, A.; Spengler, U.; Gerken, G.; Dalekos, G. N.; Wedemeyer, H.; Manns, M. P. (2006)

Acute hepatitis B progresses to liver failure with the need of liver transplantation in about 1% of cases. We treated patients with severe acute or fulminant hepatitis B with lamivudine in an attempt to prevent hepatitis ...

Safety and efficacy of small incision, sutureless pars plana vitrectomy for patients with posterior segment complications secondary to uveitis

Androudi, S.; Praidou, A.; Symeonidis, C.; Tsironi, E.; Iaccheri, B.; Fiore, T.; Tsinopoulos, I.; Brazitikos, P. (2012)

Safety and Efficacy of Transcatheter Arterial Chemoemboliazation in the Real-Life Management of Unresectable Hepatocellular Carcinoma

Mazioti, A.; Gatselis, N. K.; Rountas, C.; Zachou, K.; Filippiadis, D. K.; Tepetes, K.; Koukoulis, G. K.; Fezoulidis, I.; Dalekos, G. N. (2013)

Background: Trans-arterial chemoembolization (TACE) is associated with better survival in BCLC-stage B patients with hepatocellular carcinoma (HCC) and Child-Pugh A whereas in Child-Pugh B there is no definite evidence of ...

Safety and Outcome of Percutaneous Nephrolithotomy in the Elderly: Retrospective Comparison to a Younger Patient Group

Anagnostou, T.; Thompson, T.; Ng, C. F.; Moussa, S.; Smith, G.; Tolley, D. A. (2008)

Aim: To evaluate whether the overall safety and efficacy profile of percutaneous surgery for urinary stone disease in older (> 70 years) patients might influence the decision for the procedure in the elderly. Materials and ...

Safety and reproductive safety of moxidectin in goats

Mavrogianni, V. S.; Fthenakis, G. C.; Papadopoulos, E.; Skoufos, J.; Christodoulopoulos, G.; Tzora, A. (2004)

Various aspects of the safety of moxidectin for goats were tested in six experiments, where two pharmaceutical forms (1% injectable solution and 0.1% oral drench) of the drug were used. In experiments I and II, the drug ...

Safety and tolerability of β 3-adrenoceptor agonists in the treatment of overactive bladder syndrome - Insight from transcriptosome and experimental studies

Michel M.C., Gravas S. (2016)

Introduction: We have reviewed the safety and tolerability of β3-adrenoceptor agonists, specifically mirabegron and solabegron, a newly emerging drug class for the treatment of the overactive bladder syndrome. We discuss ...

Safety of Anticoagulation in Patients Treated with Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation

Giustozzi M., Acciarresi M., Agnelli G., Caso V., Bandini F., Tsivgoulis G., Yaghi S., Furie K.L., Tadi P., Becattini C., Zedde M., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., D'Amore C., Giulia Mosconi M., Anna Cimini L., Bovi P., Carletti M., Rigatelli A., Cappellari M., Putaala J., Tomppo L., Tatlisumak T., Marcheselli S., Pezzini A., Poli L., Padovani A., Vannucchi V., Sohn S.-I., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Ntaios G., Athanasakis G., Makaritsis K., Karagkiozi E., Vadikolias K., Liantinioti C., Theodorou A., Halvatsiotis P., Mumoli N., Galati F., Sacco S., Tiseo C., Corea F., Ageno W., Bellesini M., Silvestrelli G., Ciccone A., Lanari A., Scoditti U., Denti L., Mancuso M., Ferrari E., Ulivi L., Orlandi G., Giannini N., Tassinari T., Luisa De Lodovici M., Rueckert C., Baldi A., Toni D., Letteri F., Giuntini M., Maria Lotti E., Flomin Y., Pieroni A., Kargiotis O., Karapanayiotides T., Monaco S., Maimone Baronello M., Csiba L., Szabó L., Chiti A., Giorli E., Del Sette M., Imberti D., Zabzuni D., Doronin B., Volodina V., Michel P., Vanacker P., Barlinn K., Barlinn J., Deleu D., Gourbali V., Paciaroni M., Masotti L. (2020)

Background and Purpose: The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical ...

Safety of home-based cardiac rehabilitation: A systematic review

Stefanakis M., Batalik L., Antoniou V., Pepera G. (2022)

Background: Cardiac rehabilitation is an evidence-based intervention that aims to improve health outcomes in cardiovascular disease patients, but it is largely underutilized. One strategy for improving utilization is ...