Sfoglia per Soggetto "GENE-EXPRESSION"
Items 1-20 di 56
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1,25-Dihydroxyvitamin D-3 and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytes
(2012)Hypertrophy and impaired mineralization are two processes closely associated with osteoarthritis (OA). 1,25-dihydroxyvitamin D-3 (1a,25(OH)(2)D-3) and inorganic phosphate (Pi) are two important factors that are implicated ... -
The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells
(2011)Although leptin has been found to be implicated in obesity-related breast carcinogenesis in postmenopausal women, the molecular mechanisms involved are yet to be defined. Recently, the antiapoptotic gene survivin has been ... -
Acute resistance exercise results in catecholaminergic rather than hypothalamic-pituitary-adrenal axis stimulation during exercise in young men
(2010)Exercise is a paradigm of a stress situation. The adaptive response to stressors comprises the activation of the hypothalamic-pituitary-adrenal (HPA) axis and components of the autonomic sympathetic system. An aseptic ... -
Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding
(2005)Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ... -
Calprotectin, Calgranulin C, and Other Members of the S100 Protein Family in Inflammatory Bowel Disease
(2011)Background Since their discovery, S100 proteins have been associated with diverse diseases of inflammatory, degenerative, or malignant nature. Due to their participation in inflammation, they have also been studied with ... -
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
(2010)Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen conditions, embryogenesis ... -
Chemoprevention of liver cancer by plant polyphenols
(2012)Primary liver cancer or hepatocellular carcinoma (HCC) is one of the most frequent tumors representing the fifth commonest malignancy worldwide and the third cause of mortality from cancer. Currently, the treatments for ... -
Clinical implications for Vascular Endothelial Growth Factor in the lung: friend or foe?
(2006)Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis which has multiple effects in lung development and physiology. VEGF is expressed in several parts of the lung and the pleura while it has been ... -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
(2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
(2004)Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ... -
Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4 alpha
(2004)Hepatocyte nuclear factor-4alpha (HNF-4alpha), a member of the nuclear receptor superfamily, is a crucial regulator of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism. Unlike other members ... -
Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies
(2011)Pancreatic autoantibodies (PAB) giving characteristic staining patterns of the exocrine pancreas by indirect immunoflourescence appear to be specific markers of Crohn's disease (CrD), being present in approximarely 30% of ... -
Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
(2009)The Y-box protein-1 (YB-1) belongs to the family of cold shock proteins that have pleiotropic functions such as gene transcription, RNA splicing, and mRNA translation. YB-1 has a critical role in atherogenesis due to its ... -
Digoxin and Adenosine Triphosphate Enhance the Functional Properties of Tissue-Engineered Cartilage
(2015)Toward developing engineered cartilage for the treatment of cartilage defects, achieving relevant functional properties before implantation remains a significant challenge. Various chemical and mechanical stimuli have been ... -
DNA damage and repair capacity in lymphocytes from obstructive sleep apnea patients
(2007)Obstructive sleep apnea (OSA) syndrome is a respiratory disease that is linked to heart attacks and high blood pressure. In the present study, we used the Comet assay to compare basal DNA damage and DNA damage induction ... -
The effect of dexamethasone on tissue fibrinolytic system in male and female rats
(1999)Background: Dexamethasone in low and high doses affects blood fibrinolytic activity both in animals and humans. In this study the effect of a high dose of dexamethasone on plasminogen activator activity (PAA), t-PA antigen ... -
Effect of musical stimuli and white noise on rainbow trout (Oncorhynchus mykiss) growth and physiology in recirculating water conditions
(2013)Two musical stimuli transmissions (Mozart and Romanza) as compared with white noise treatment or control, both resulted in significantly higher growth performance in juvenile (6.7 +/- 0.12 g) rainbow trout (Oncorhynchus ... -
Effects of dietary vitamin A intake on acrosin- and plasminogen-activator activity of ram spermatozoa
(2005)Acrosin and plasminogen activators are proteolytic enzymes of ram spermatozoa that play an essential role in the induction of the acrosome reaction, as well as the binding of spermatozoa to the oocyte and their penetration ... -
eIF2 alpha Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1 alpha
(2010)Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1 alpha (HIF-1 alpha), cells also respond to hypoxia by ... -
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2
(2009)SR protein kinases (SRPKs) phosphorylate Ser/Arg dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes. Phosphorylation by SRPKs constitutes a major way of regulating such ...