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  •   University of Thessaly Institutional Repository
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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Chemoprevention of liver cancer by plant polyphenols

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Author
Stagos, D.; Amoutzias, G. D.; Matakos, A.; Spyrou, A.; Tsatsakis, A. M.; Kouretas, D.
Date
2012
DOI
10.1016/j.fct.2012.04.002
Keyword
Liver cancer
Chemoprevention
Plant polyphenols
HUMAN HEPATOCELLULAR-CARCINOMA
HUMAN HEPATOMA-CELLS
ACID PHENETHYL
ESTER
CAPSAICIN-INDUCED APOPTOSIS
GREEN TEA POLYPHENOL
ENDOPLASMIC-RETICULUM STRESS
OXIDASE-MEDIATED GENERATION
IMPLANTED
NUDE-MICE
NF-KAPPA-B
GENE-EXPRESSION
Food Science & Technology
Toxicology
Metadata display
Abstract
Primary liver cancer or hepatocellular carcinoma (HCC) is one of the most frequent tumors representing the fifth commonest malignancy worldwide and the third cause of mortality from cancer. Currently, the treatments for HCC are not so effective and new strategies are needed for its fight. Chemoprevention, the use of natural or synthetic chemical agents to reverse, suppress or prevent carcinogenesis is considered an important way for confronting HCC. Many of the chemopreventive agents are phytochemicals, namely non-nutritive plant chemicals with protective or disease preventive properties. In this review, we focus on plant polyphenols, one of the most important classes of phytochemicals, their chemopreventive properties against HCC and discuss the molecular mechanisms accounting for this activity. (C) 2012 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/11615/33323
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