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  •   Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας
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  •   Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας
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Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

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Συγγραφέας
Wang L., Heckman M.G., Aasly J.O., Annesi G., Bozi M., Chung S.J., Clarke C., Crosiers D., Eckstein G., Garraux G., Hadjigeorgiou G.M., Hattori N., Jeon B., Kim Y.J., Kubo M., Lesage S., Lin J.J., Lynch T., Lichtner P., Mellick G.D., Mok V., Morrison K.E., Quattrone A., Satake W., Silburn P.A., Stefanis L., Stockton J.D., Tan E.K., Toda T., Brice A., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M., Gasser T., Krüger R., Farrer M.J., Ross O.A., Sharma M.
Ημερομηνία
2017
Γλώσσα
en
DOI
10.1016/j.neurobiolaging.2016.09.022
Λέξη-κλειδί
leucine rich repeat kinase 2
leucine rich repeat kinase 2
LRRK2 protein, human
Article
controlled study
gene
gene frequency
gene interaction
gene locus
genetic risk
genetic variability
genotype
human
LRRK2 gene
lysosome
major clinical study
PARK16 gene
Parkinson disease
priority journal
single nucleotide polymorphism
epistasis
gene locus
genetic association study
genetic predisposition
genetic variation
genetics
multicenter study (topic)
Parkinson disease
risk
Epistasis, Genetic
Genetic Association Studies
Genetic Loci
Genetic Predisposition to Disease
Genetic Variation
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Multicenter Studies as Topic
Parkinson Disease
Risk
Elsevier Inc.
Εμφάνιση Μεταδεδομένων
Επιτομή
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. © 2016 Elsevier Inc.
URI
http://hdl.handle.net/11615/80779
Collections
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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