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Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group

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Auteur
Velissaris D., Dimopoulos G., Parissis J., Alexiou Z., Antonakos N., Babalis D., Gerakari S., Kaldis V., Koutoukas P., Lada M., Leventogiannis K., Pantazopoulos I., Papadopoulos A., Polyzogopoulou E., Gogos C., Armaganidis A., Giamarellos-Bourboulis E.J.
Date
2020
Language
en
DOI
10.1007/s40121-020-00301-w
Sujet
plasminogen
tumor necrosis factor
urokinase
urokinase receptor
algorithm
angiogenesis
APACHE
artificial ventilation
cell proliferation
chronic kidney failure
coronary angiography
disease severity
e-mail
emergency ward
extracorporeal oxygenation
genotype
glomerulosclerosis
glomerulus filtration rate
hospital mortality
human
intensive care unit
length of stay
leukocyte count
multiple organ failure
Note
practice guideline
priority journal
prostate cancer
proteinuria
rheumatoid arthritis
risk assessment
septic shock
Sequential Organ Failure Assessment Score
Adis
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Résumé
In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious diseases frame a position statement on the role of suPAR in the screening of patients admitted to the emergency department. The statement is framed taking into consideration existing publications and our own research experience. The main content of this statement is that sUPAR is a non-specific marker associated with a high negative predictive value for unfavourable outcomes; levels < 4 ng/ml indicate that it is safe to discharge the patient, whereas levels > 6 ng/ml are an alarming sign of risk for unfavourable outcomes. However, the suPAR levels should always be interpreted in light of the patient's history. © 2020, The Author(s).
URI
http://hdl.handle.net/11615/80567
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]
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