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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Nasal high-flow oxygen versus noninvasive ventilation in acute exacerbation of copd: Protocol for a randomised noninferiority clinical trial

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Autor
Papalampidou A., Bibaki E., Boutlas S., Pantazopoulos I., Athanasiou N., Moylan M., Vlachakos V., Grigoropoulos V., Eleftheriou K., Daniil Z., Gourgoulianis K., Kalomenidis I., Zakynthinos S., Ischaki E.
Fecha
2020
Language
en
DOI
10.1183/23120541.00114-2020
Materia
acidemia
arterial oxygen saturation
Article
blood carbon dioxide tension
breathing mechanics
breathing muscle
breathing rate
chronic obstructive lung disease
comparative study
controlled study
flow rate
forced expiratory volume
forced vital capacity
Glasgow coma scale
heart arrest
heart arrhythmia
heart supraventricular arrhythmia
hemodynamics
high flow nasal cannula therapy
hospitalization
human
hypoxemia
major clinical study
multicenter study
noninvasive ventilation
outcome assessment
pneumothorax
positive pressure ventilation
prospective study
pulse oximetry
randomized controlled trial
respiratory failure
thoracoabdominal asynchrony
treatment failure
visual analog scale
European Respiratory Society
Mostrar el registro completo del ítem
Resumen
Background: Noninvasive ventilation (NIV) is considered as the first-line treatment for acute exacerbation of COPD (AECOPD) complicated by respiratory acidosis. Recent studies demonstrate a role of nasal high-flow oxygen (NHF) in AECOPD as an alternative treatment in patients intolerant to NIV or with contraindications to it. Aim: The study aimed to evaluate whether NHF respiratory support is noninferior compared to NIV in respect to treatment failure, defined as need for intubation or change to alternative treatment group, in patients with AECOPD and mild-to-moderate acute or acute-on-chronic hypercapnic respiratory failure. Methods: We designed a multicentre, prospective, randomised trial on patients with AECOPD, who have pH<7.35 but >7.25 and PaCO2 >45 mmHg, in whom NIV is indicated as a first-line treatment. According to power analysis, 498 participants will be required for establishing noninferiority of NHF compared to NIV. Patients will be randomly assigned to receive NIV or NHF. Treatment will be adjusted to maintain SpO2 between 88%–92% for both groups. Arterial blood gases, respiratory variables, comfort, dyspnoea score and any pulmonary or extrapulmonary complications will be assessed at baseline, before treatment initiation, and at 1, 2, 4, 6, 12, 24, 48 h, then once daily from day 3 to patient discharge, intubation or death. Conclusion: Given the increasing number of studies demonstrating the physiological effects of NHF in COPD patients, we hypothesise that NHF respiratory support will be noninferior to NIV in patients with AECOPD and mild-to-moderate acute or acute on chronic hypercapnic respiratory failure. © ERS 2020.
URI
http://hdl.handle.net/11615/77749
Colecciones
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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