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A meta-analysis of FZD3 gene polymorphisms and their association with schizophrenia

Thumbnail
Autore
Pantavou K.G., Braliou G.G., Kontou P.I., Dimou N.L., Bagos P.G.
Data
2016
Language
en
DOI
10.1097/YPG.0000000000000155
Soggetto
frizzled 3 protein
frizzled protein
unclassified drug
frizzled protein
FZD3 protein, human
allele
Article
Chinese
gene linkage disequilibrium
genetic association
genetic association study
genetic polymorphism
genetic risk
genome-wide association study
genotype
human
priority journal
schizophrenia
sensitivity analysis
single nucleotide polymorphism
systematic review
adult
Asian continental ancestry group
female
gene frequency
genetic predisposition
genetics
male
meta analysis
metabolism
middle aged
procedures
schizophrenia
Adult
Alleles
Asian Continental Ancestry Group
Female
Frizzled Receptors
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Schizophrenia
Lippincott Williams and Wilkins
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Abstract
Objective The aim of this study was to investigate the potential association of FZD3 polymorphisms with schizophrenia. Methods A systematic review and a meta-analysis were carried out comprising of nine genetic association studies, with both a population-based and a family-based design, and three genome-wide association studies. A total of 1601 family trios, 39 922 schizophrenic patients, and 61 287 healthy individuals were involved in the analysis and six polymorphisms were examined: rs2241802, rs2323019, rs352203, rs3757888, rs880481, and rs960914. A summary-based method for pooling genetic association studies under both family-based and population-based designs was used. Odds ratios along with their 95% confidence intervals were computed to compare the contrast of alleles in patients and controls. Results The results indicate a potentially weaker effect of FZD3 polymorphisms on schizophrenia than that suggested originally and possibly limited to Chinese populations. No relationship was identified between all examined polymorphisms and schizophrenia, except for rs352203, which plays a protective role against schizophrenia. However, this effect was mainly attributed to studies including Chinese patients. In the Chinese population, evidence for an elevated risk for schizophrenia linked to the rs2323019 polymorphism was also identified. Conclusion Given the different linkage disequilibrium patterns observed in Chinese populations, schizophrenia may be related to some other polymorphisms of gene FZD3 that are in stronger linkage disequilibrium to Chinese than to the other populations studied. © 2016 Wolters Kluwer Health, Inc.
URI
http://hdl.handle.net/11615/77499
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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