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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
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Carotid Atherosclerosis and Patent Foramen Ovale in Embolic Stroke of Undetermined Source

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Autor
Ntaios G., Sagris D., Strambo D., Perlepe K., Sirimarco G., Georgiopoulos G., Nannoni S., Korompoki E., Manios E., Makaritsis K., Vemmos K., Michel P.
Fecha
2021
Language
en
DOI
10.1016/j.jstrokecerebrovasdis.2020.105409
Materia
adult
aged
Article
cardioembolic stroke
carotid atherosclerosis
cerebrovascular accident
comparative study
diabetes mellitus
dyslipidemia
embolic stroke of undetermined source
female
human
hypertension
major clinical study
male
obesity
patent foramen ovale
pathogenesis
pathogenicity
prevalence
priority journal
risk of paradoxical embolism score
scoring system
smoking
transesophageal echocardiography
transient ischemic attack
transthoracic echocardiography
carotid artery disease
clinical trial
diagnostic imaging
incidence
middle aged
multicenter study
patent foramen ovale
retrospective study
risk assessment
risk factor
Adult
Aged
Carotid Artery Diseases
Embolic Stroke
Female
Foramen Ovale, Patent
Humans
Incidence
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Assessment
Risk Factors
W.B. Saunders
Mostrar el registro completo del ítem
Resumen
Background: Carotid atherosclerosis and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms among ESUS patients remains unclear. Aim: To investigate the relation between carotid atherosclerosis and likely pathogenic PFO in patients with ESUS. We hypothesized that ipsilateral carotid atherosclerotic plaques are less prevalent in ESUS with likely pathogenic PFO compared to patients with likely incidental PFO or without PFO. Methods: The presence of PFO was assessed with transthoracic echocardiography with microbubble test and, when deemed necessary, through trans-oesophageal echocardiography. The presence of PFO was considered as likely incidental if the RoPE (Risk of Paradoxical Embolism) score was 0–6 and likely pathogenic if 7–10. Results: Among 374 ESUS patients (median age: 61years, 40.4% women), there were 63 (49.6%) with likely incidental PFO, 64 (50.4%) with likely pathogenic PFO and 165 (44.1%) with ipsilateral carotid atherosclerosis. The prevalence of ipsilateral carotid atherosclerosis was lower in patients with likely pathogenic PFO (7.8%) compared to patients with likely incidental PFO (46.0%) or patients without PFO (53.0%) (p<0.001). After adjustment for multiple confounders, the prevalence of ipsilateral carotid atherosclerosis remained lower in patients with likely pathogenic PFO compared to patients with likely incidental PFO or without PFO (adjusted OR=0.32, 95%CI:0.104-0.994, p=0.049). Conclusions: The presence of carotid atherosclerosis is inversely related to the presence of likely pathogenic PFO in patients with ESUS. © 2020 Elsevier Inc.
URI
http://hdl.handle.net/11615/77297
Colecciones
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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