Motor function and the probability of prodromal Parkinson's disease in older adults
dc.creator | Maraki M.I., Stefanis L., Yannakoulia M., Kosmidis M.H., Xiromerisiou G., Dardiotis E., Hadjigeorgiou G.M., Sakka P., Scarmeas N., Stamelou M. | en |
dc.date.accessioned | 2023-01-31T08:57:15Z | |
dc.date.available | 2023-01-31T08:57:15Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1002/mds.27792 | |
dc.identifier.issn | 08853185 | |
dc.identifier.uri | http://hdl.handle.net/11615/76334 | |
dc.description.abstract | Background: Identification and characterization of Parkinson's disease (PD) in its prodromal stage is crucial. Objective: The objective of this study was to investigate the association between motor function and the probability of prodromal PD in a community-dwelling older population. Methods: We used data from a population-based cohort of older adults (HELIAD study). Subjective motor function was evaluated with a 12-item motor symptoms questionnaire and objective motor function indirectly with a physical activity questionnaire and two gait speed tests. The probability of prodromal PD was calculated according to the Movement Disorder Society research criteria for n = 1731 without PD. Regression multiadjusted models were used to investigate the associations between each motor measure and prodromal PD probability. Results: For each unit increase in motor symptoms score and for each kcal/kg/day lower energy expenditure (corresponding to 20 minutes of light walking/day for a 75-kg man) there was a 27% and 3% higher probability for prodromal PD, respectively (P ' 0.001). Having at least one subjective motor symptom increased the odds of having possible/probable prodromal PD (n = 49; P ' 0.05). Including subjective and indirect motor variables in the same model showed that both (symptoms and physical activity) contributed significantly to the model (P ' 0.01). Excluding subthreshold parkinsonism from the calculation showed that gait speed less than 0.8 m/s was also associated with a higher prodromal PD probability score (P ' 0.001). Conclusions: Subjective motor symptoms as well as simple objective motor measures of physical activity or gait speed are associated with a higher probability of prodromal PD in older adults. These data may serve to enable the early identification of prodromal PD cohorts, particularly if they are confirmed in longitudinal studies. © 2019 International Parkinson and Movement Disorder Society. © 2019 International Parkinson and Movement Disorder Society | en |
dc.language.iso | en | en |
dc.source | Movement Disorders | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069859712&doi=10.1002%2fmds.27792&partnerID=40&md5=4df1b5e59f90271c309166923418d433 | |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | calculation | en |
dc.subject | cohort analysis | en |
dc.subject | energy expenditure | en |
dc.subject | evaluation study | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | medical society | en |
dc.subject | motor performance | en |
dc.subject | Parkinson disease | en |
dc.subject | parkinsonism | en |
dc.subject | physical activity | en |
dc.subject | priority journal | en |
dc.subject | questionnaire | en |
dc.subject | symptom assessment | en |
dc.subject | walking speed | en |
dc.subject | depression | en |
dc.subject | energy metabolism | en |
dc.subject | gait | en |
dc.subject | Greece | en |
dc.subject | longitudinal study | en |
dc.subject | middle aged | en |
dc.subject | motor dysfunction | en |
dc.subject | movement (physiology) | en |
dc.subject | Parkinson disease | en |
dc.subject | probability | en |
dc.subject | prodromal symptom | en |
dc.subject | psychological rating scale | en |
dc.subject | psychology | en |
dc.subject | socioeconomics | en |
dc.subject | very elderly | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Cohort Studies | en |
dc.subject | Depression | en |
dc.subject | Energy Metabolism | en |
dc.subject | Female | en |
dc.subject | Gait | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Longitudinal Studies | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Movement | en |
dc.subject | Movement Disorders | en |
dc.subject | Parkinson Disease | en |
dc.subject | Probability | en |
dc.subject | Prodromal Symptoms | en |
dc.subject | Psychiatric Status Rating Scales | en |
dc.subject | Socioeconomic Factors | en |
dc.subject | Surveys and Questionnaires | en |
dc.subject | John Wiley and Sons Inc. | en |
dc.title | Motor function and the probability of prodromal Parkinson's disease in older adults | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |