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DIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactions

dc.creatorKaragkouni D., Paraskevopoulou M.D., Chatzopoulos S., Vlachos I.S., Tastsoglou S., Kanellos I., Papadimitriou D., Kavakiotis I., Maniou S., Skoufos G., Vergoulis T., Dalamagas T., Hatzigeorgiou A.G.en
dc.date.accessioned2023-01-31T08:30:50Z
dc.date.available2023-01-31T08:30:50Z
dc.date.issued2018
dc.identifier10.1093/nar/gkx1141
dc.identifier.issn03051048
dc.identifier.urihttp://hdl.handle.net/11615/74357
dc.description.abstractDIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, corresponding to ∼4670 000 unique miRNA-target pairs. The interactions are supported by >33 experimental methodologies, applied to ∼4600 cell types/tissues under ∼4451 experimental conditions. It integrates information on cell-type specific miRNA-gene regulation, while hundreds of thousands of miRNA-binding locations are reported. TarBase is coming of age, with more than a decade of continuous support in the non-coding RNA field. A new module has been implemented that enables the browsing of interactions through different filtering combinations. It permits easy retrieval of positive and negative miRNA targets per species, methodology, cell type and tissue. An incorporated ranking system is utilized for the display of interactions based on the robustness of their supporting methodologies. Statistics, pie-charts and interactive bar-plots depicting the database content are available through a dedicated result page. An intuitive interface is introduced, providing a user-friendly application with flexible options to different queries. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.en
dc.language.isoenen
dc.sourceNucleic Acids Researchen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040943205&doi=10.1093%2fnar%2fgkx1141&partnerID=40&md5=e59b4f5d59f83d85ef4767a77c0810a5
dc.subjectmicroRNAen
dc.subjectuntranslated RNAen
dc.subjectmicroRNAen
dc.subjectArticleen
dc.subjectcells by body anatomyen
dc.subjectDIANA TarBaseen
dc.subjectexperimental studyen
dc.subjectgene controlen
dc.subjectgene interactionen
dc.subjectgene sequenceen
dc.subjectgene targetingen
dc.subjecthigh throughput sequencingen
dc.subjecthumanen
dc.subjectmethodologyen
dc.subjectpriority journalen
dc.subjectreference databaseen
dc.subjectscientisten
dc.subjectanimalen
dc.subjectcomputer interfaceen
dc.subjectDNA microarrayen
dc.subjectepistasisen
dc.subjectgeneticsen
dc.subjectmetabolismen
dc.subjectnucleic acid databaseen
dc.subjectsequence analysisen
dc.subjectAnimalsen
dc.subjectDatabases, Nucleic Aciden
dc.subjectEpistasis, Geneticen
dc.subjectHigh-Throughput Nucleotide Sequencingen
dc.subjectHumansen
dc.subjectMicroRNAsen
dc.subjectOligonucleotide Array Sequence Analysisen
dc.subjectSequence Analysis, RNAen
dc.subjectUser-Computer Interfaceen
dc.subjectOxford University Pressen
dc.titleDIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactionsen
dc.typejournalArticleen


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