Application of a One-Dimensional Computational Model for the Prediction of Deposition from a Dry Powder Inhaler
Date
2017Language
en
Keyword
Abstract
Background: Accurate prediction of the regional deposition of inhaled dry powders as a function of powder properties and breathing pattern is a long-term research goal for pulmonary drug delivery. In the present work, deposition along the respiratory tract of dry powders of Fluticasone propionate and Salmeterol is predicted. Methods: A one-dimensional particle transport and deposition model is used, whose novelty is in the treatment of the alveolar space of each airway generation as an efficient mixing chamber. This assumption has been supported by simulations and measurements during the last 20 years. The model is applied to two popular pulmonary tree geometries, to investigate the effect of particle size on localized deposition and to estimate the uncertainty due to variations in airway size. Results and Conclusions: Application of the model for the specific particle size distribution measured by a cascade impactor in the marketed product ELPENhaler, predicts the whole lung deposition (WLD), as well as the split between pulmonary (PU) and tracheobronchial (TB) deposition. Introduction in the model of modified particle size distributions with increased fractions of fine particles, indicates that the fine-particle dose is a satisfactory predictor of WLD but not of the PU/TB ratio. © 2017, Mary Ann Liebert, Inc.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Airborne algae and cyanobacteria: Occurrence and related health effects
Genitsaris, S.; Kormas, K. A.; Moustaka-Gouni, M. (2011)Published information on airborne algae and cyanobacteria worldwide and the related human health effects is scarce. Since 1844, a total of 353 morphological taxa (genera or species) have been identified in aerobiological ... -
A comparison of propofol, thiopental or ketamine as induction agents in goats
Prassinos, N. N.; Galatos, A. D.; Raptopoulos, D. (2005)Objective: To compare propofol, thiopental and ketamine as induction agents before halothane anaesthesia in goats. Study design: Prospective, randomized cross-over study. Animals: Seven healthy adult female goats with mean ... -
Inhaled drug consumption and asthma mortality in Greece [2]
Melissinos, C. G.; Gourgoulianis, K.; Adamidis, S. C. (1995)