dc.creator | Giannopoulou M., Tarassi K., Tsouka G., Christodoulidou C., Stefanidis I., Eleftheriadis T. | en |
dc.date.accessioned | 2023-01-31T07:42:01Z | |
dc.date.available | 2023-01-31T07:42:01Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.6002/ect.2022.0146 | |
dc.identifier.issn | 13040855 | |
dc.identifier.uri | http://hdl.handle.net/11615/72338 | |
dc.description.abstract | Chronic active antibody-mediated rejection is the leading cause of kidney transplant failure. Although various immunosuppressive agents have been tested, rituximab included, presently there is no effective treatment. There are reports about the beneficial role of certain immunosuppressive protocols that include rituximab to reduce donor-specific antibodies, the cause of chronic active antibody-mediated rejection. If an immunosuppressive agent reduces donor-specific antibodies, its administration before the occurrence of chronic active antibody-mediated rejection may be beneficial. We describe a case of a renal transplant recipient with recurrent membranous nephropathy and recent development of donor-specific antibodies but without histological evidence of active antibody-mediated rejection. The patient received 3 weekly doses of rituximab for recurrent membranous nephropathy, and complete remission was achieved. One year after, he has preserved an excellent renal function without proteinuria. However, repeated measurements of donor-specific antibodies revealed that rituximab only modestly reduced donor-specific antibodies. Donor-specific antibody levels remained considerably higher than the laboratory reference value. Thus, rituximab alone may not have a role to prevent chronic active antibody-mediated rejection in patients with donor-specific antibodies. © Başkent University 2022 Printed in Turkey. All Rights Reserved. | en |
dc.language.iso | en | en |
dc.source | Experimental and Clinical Transplantation | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135501013&doi=10.6002%2fect.2022.0146&partnerID=40&md5=e0430dadee1e2e77aa34cbec206842ba | |
dc.subject | antibody | en |
dc.subject | basiliximab | en |
dc.subject | creatinine | en |
dc.subject | donor specific antibody | en |
dc.subject | HLA antigen | en |
dc.subject | HLA antigen class 1 | en |
dc.subject | HLA antigen class 2 | en |
dc.subject | HLA DQ4 antibody | en |
dc.subject | HLA DQ5 antibody | en |
dc.subject | HLA DQ6 antibody | en |
dc.subject | HLA DQA1 antibody | en |
dc.subject | HLA DR51 antibody | en |
dc.subject | methylprednisolone | en |
dc.subject | mycophenolic acid | en |
dc.subject | phospholipase A2 receptor | en |
dc.subject | rituximab | en |
dc.subject | tacrolimus | en |
dc.subject | unclassified drug | en |
dc.subject | antibody | en |
dc.subject | immunosuppressive agent | en |
dc.subject | rituximab | en |
dc.subject | adult | en |
dc.subject | antibody detection | en |
dc.subject | antibody mediated rejection | en |
dc.subject | Article | en |
dc.subject | case report | en |
dc.subject | clinical article | en |
dc.subject | creatinine blood level | en |
dc.subject | end stage renal disease | en |
dc.subject | graft recipient | en |
dc.subject | hemodialysis | en |
dc.subject | histology | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | immunosuppressive treatment | en |
dc.subject | kidney biopsy | en |
dc.subject | kidney donor | en |
dc.subject | kidney transplantation | en |
dc.subject | living donor | en |
dc.subject | male | en |
dc.subject | membranous glomerulonephritis | en |
dc.subject | proteinuria | en |
dc.subject | wife | en |
dc.subject | adverse event | en |
dc.subject | graft rejection | en |
dc.subject | membranous glomerulonephritis | en |
dc.subject | pathology | en |
dc.subject | treatment outcome | en |
dc.subject | Antibodies | en |
dc.subject | Glomerulonephritis, Membranous | en |
dc.subject | Graft Rejection | en |
dc.subject | Humans | en |
dc.subject | Immunosuppressive Agents | en |
dc.subject | Kidney Transplantation | en |
dc.subject | Male | en |
dc.subject | Rituximab | en |
dc.subject | Treatment Outcome | en |
dc.subject | Baskent University | en |
dc.title | Rituximab Administered for Recurrent Membranous Nephropathy in a Kidney Transplant Recipient Did Not Eliminate Donor-Specific Antibodies | en |
dc.type | journalArticle | en |