dc.creator | Giagkou N., Maraki M.I., Yannakoulia M., Kosmidis M.H., Dardiotis E., Hadjigeorgiou G.M., Sakka P., Ntanasi E., Anastasiou C.A., Xiromerisiou G., Stefanis L., Scarmeas N., Stamelou M. | en |
dc.date.accessioned | 2023-01-31T07:41:32Z | |
dc.date.available | 2023-01-31T07:41:32Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1002/mds.28145 | |
dc.identifier.issn | 08853185 | |
dc.identifier.uri | http://hdl.handle.net/11615/72265 | |
dc.description.abstract | Objective: The objective of this study was to validate the recently updated research criteria for prodromal Parkinson's disease (pPD) proposed by the International Parkinson's Disease and Movement Disorders Society. Methods: A total of 16 of 21 markers of pPD were ascertained in the Hellenic Longitudinal Investigation of Aging and Diet cohort composed of community-dwelling individuals aged ≥65 years. The probability of pPD was calculated for 961 individuals without Parkinson's disease (PD) or dementia with Lewy bodies at baseline who were followed-up for a median of 3 years. The ability of the criteria to predict conversion to PD/dementia with Lewy bodies was assessed by estimating their sensitivity and specificity, plotting receiver operating characteristics curves, and using logistic regression. These analyses were repeated using the original criteria. Results: No incident PD/dementia with Lewy bodies case had probable pPD at baseline (ie, ≥80% pPD probability). At cut-offs of 10%, 30%, and 50% probability of pPD, the sensitivity and specificity of the criteria ranged from 4.5% to 27.3%, and 85.7% to 98.3% respectively. The area under the receiver operating characteristics curve was 0.691 (95% confidence intervals, 0.605–0.777). In logistic regression models, the criteria-derived posttest odds of pPD were a significant predictor of conversion at follow-up. The updated criteria performed similarly to the original but showed a slight increase in sensitivity. Conclusions: The new criteria demonstrated suboptimal sensitivity in our random sample of community-dwelling individuals. The absence of specialized assessments with high likelihood ratios in our cohort could be hindering the demonstration of higher sensitivities. Such assessments should be a part of future validation attempts. © 2020 International Parkinson and Movement Disorder Society. © 2020 International Parkinson and Movement Disorder Society | en |
dc.language.iso | en | en |
dc.source | Movement Disorders | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087299549&doi=10.1002%2fmds.28145&partnerID=40&md5=b6d04526a6488e86d569306d75ecda1e | |
dc.subject | pesticide | en |
dc.subject | aged | en |
dc.subject | anxiety disorder | en |
dc.subject | Article | en |
dc.subject | clinical assessment | en |
dc.subject | clinical examination | en |
dc.subject | clinical research | en |
dc.subject | coffee | en |
dc.subject | community dwelling person | en |
dc.subject | controlled study | en |
dc.subject | depression | en |
dc.subject | diagnostic accuracy | en |
dc.subject | diffuse Lewy body disease | en |
dc.subject | disease marker | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | Geriatric Depression Scale | en |
dc.subject | Hospital Anxiety and Depression Scale | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | medical society | en |
dc.subject | motor dysfunction | en |
dc.subject | neurologic examination | en |
dc.subject | neuropsychiatric inventory | en |
dc.subject | Parkinson disease | en |
dc.subject | priority journal | en |
dc.subject | probability | en |
dc.subject | prodromal symptom | en |
dc.subject | random sample | en |
dc.subject | receiver operating characteristic | en |
dc.subject | risk | en |
dc.subject | sensitivity and specificity | en |
dc.subject | sleep disorder | en |
dc.subject | Unified Parkinson Disease Rating Scale | en |
dc.subject | validation study | en |
dc.subject | Alzheimer disease | en |
dc.subject | cohort analysis | en |
dc.subject | Parkinson disease | en |
dc.subject | prodromal symptom | en |
dc.subject | prospective study | en |
dc.subject | Aged | en |
dc.subject | Alzheimer Disease | en |
dc.subject | Cohort Studies | en |
dc.subject | Humans | en |
dc.subject | Parkinson Disease | en |
dc.subject | Prodromal Symptoms | en |
dc.subject | Prospective Studies | en |
dc.subject | John Wiley and Sons Inc | en |
dc.title | A Prospective Validation of the Updated Movement Disorders Society Research Criteria for Prodromal Parkinson's Disease | en |
dc.type | journalArticle | en |