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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Exercise in glucose-6-phosphate dehydrogenase deficiency: Harmful or harmless? A narrative review

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Autor
Georgakouli K., Fatouros I.G., Draganidis D., Papanikolaou K., Tsimeas P., Deli C.K., Jamurtas A.Z.
Datum
2019
Language
en
DOI
10.1155/2019/8060193
Schlagwort
Amino acids
Antioxidants
Blood
Diagnosis
Glucose
Oxidative stress
Antioxidant molecules
Beneficial effects
Clinical symptoms
Dietary supplementation
G6PD deficiency
Glucose-6-phosphate dehydrogenase
Quality of life
Red blood cell
Dietary supplements
antioxidant
cysteine
glucose 6 phosphate dehydrogenase
glutathione
vitamin
diet supplementation
exercise
glucose 6 phosphate dehydrogenase deficiency
hemolysis
human
inborn error of metabolism
myoglobinuria
nutritional deficiency
oxidative stress
quality of life
Review
symptom
vitamin supplementation
blood
glucose 6 phosphate dehydrogenase deficiency
oxidation reduction reaction
Amino Acids
Antioxidants
Blood
Cells
Cysteine
Diagnosis
Glucose
Stresses
Exercise
Glucosephosphate Dehydrogenase Deficiency
Humans
Oxidation-Reduction
Oxidative Stress
Hindawi Limited
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Zusammenfassung
Objectives. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, theoretically, renders red blood cells (RBC) susceptible to oxidative stress. G6PD deficiency has also been found in other types of cells than RBC, such as leukocytes and myocytes, where an inefficient protection against oxidative stress may occur too. Glutathione (GSH), a significant antioxidant molecule, levels are lower in G6PD individuals, and theoretically, the probability of oxidative stress and haemolysis due to exercise in individuals with G6PD deficiency is increased, whereas dietary supplementation with antioxidants may have beneficial effects on various aspects of this enzymopathy. Methods. A search of the available literature was conducted using the keywords glucose-6phosphate dehydrogenase (G6PD), deficiency, disease, exercise, muscle, antioxidant, vitamin, supplement, and supplementation. The search was limited to publications in English, conducted on humans, and published until August 2018. After screening, only relevant articles were included. Results. There is little evidence indicating that G6PD deficiency can cause perturbations in redox status, haemolysis, and clinical symptoms such as fatigability and myoglobinuria, especially after intense exercise, compared to individuals with normal enzyme levels. Conclusions. Exercise could be used by G6PD-deficient individuals as a tool to improve their quality of life. However, there is a lack of training studies, and assessment of the effects of regular and systematic exercise in G6PD-deficient individuals is warranted. Finally, since GSH levels are lower in G6PD deficiency, it would be interesting to examine the effects of antioxidant or cysteine donor supplements on redox status after exercise in these individuals. Copyright © 2019 Kalliopi Georgakouli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI
http://hdl.handle.net/11615/72080
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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