dc.creator | Bouliaris K., Asprodini E., Liakos P., Diamantis A., Koukoulis G., Befani C., Tzika S., Tepetes K. | en |
dc.date.accessioned | 2023-01-31T07:39:39Z | |
dc.date.available | 2023-01-31T07:39:39Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1016/j.jss.2018.10.003 | |
dc.identifier.issn | 00224804 | |
dc.identifier.uri | http://hdl.handle.net/11615/71947 | |
dc.description.abstract | Background: The use of surgical meshes in ventral hernia repair has significantly reduced hernia recurrence rates. However, when placed intraperitoneally prosthetic materials can trigger the development of peritoneal adhesions. The present experimental study evaluated the combined icodextrin 4% and dimetindene maleate treatment in preventing peritoneal adhesion formation to polypropylene and titanium-coated polypropylene meshes. Materials and methods: Sixty female white rabbits were divided into four groups. A 2 × 2 cm piece of mesh was fixed to intact peritoneum in all animals through a midline laparotomy. A lightweight polypropylene mesh was implanted in groups 1 and 2 and a titanium-coated polypropylene mesh in groups 3 and 4. Groups 2 and 4 were treated, intraoperatively, with intravenous dimetindene maleate (0.1 mg/kg) and intraperitoneal solution of icodextrin 4% (20 mL/kg) and for the next 6 d with dimetindene maleate intramuscularly. The observation period lasted 15 d. Adhesion scores, percentage of mesh affected surface, tissue hydroxyproline levels, and tissue histopathology were examined. Results: All animals in group 1 and 57% of animals in group 3 presented postoperative adhesions. The combination of antiadhesives significantly reduced the extent and severity of adhesions as well as the hydroxyproline levels in groups 2 and 4 compared with groups 1 and 3. On microscopic evaluation, animals in group 1 exhibited higher inflammation scores compared with group 2, whereas animals in groups 2 and 4 had better mesotheliazation compared with groups 1 and 3. Conclusions: The combined administration of icodextrin 4% and dimetindene maleate reduces the extent and severity of adhesions and may be successfully used to prevent adhesion formation after mesh intraperitoneal placement. © 2018 Elsevier Inc. | en |
dc.language.iso | en | en |
dc.source | Journal of Surgical Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055913410&doi=10.1016%2fj.jss.2018.10.003&partnerID=40&md5=ea227d2f7ce622bd38ea5c25b94a896b | |
dc.subject | 'adept' | en |
dc.subject | collagen | en |
dc.subject | dimetindene | en |
dc.subject | fenistil | en |
dc.subject | hydroxyproline | en |
dc.subject | icodextrin | en |
dc.subject | dimetindene | en |
dc.subject | icodextrin | en |
dc.subject | polypropylene | en |
dc.subject | protective agent | en |
dc.subject | abdominal wall hernia | en |
dc.subject | amino acid blood level | en |
dc.subject | animal cell | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | Article | en |
dc.subject | comparative study | en |
dc.subject | controlled study | en |
dc.subject | disease severity | en |
dc.subject | experimental study | en |
dc.subject | female | en |
dc.subject | hernioplasty | en |
dc.subject | histopathology | en |
dc.subject | laparoscopic surgery | en |
dc.subject | laparotomy | en |
dc.subject | Leporidae | en |
dc.subject | nonhuman | en |
dc.subject | peritoneum adhesion | en |
dc.subject | priority journal | en |
dc.subject | prophylaxis | en |
dc.subject | tissue adhesion | en |
dc.subject | adverse device effect | en |
dc.subject | animal | en |
dc.subject | combination drug therapy | en |
dc.subject | intramuscular drug administration | en |
dc.subject | intraperitoneal drug administration | en |
dc.subject | intravenous drug administration | en |
dc.subject | postoperative complication | en |
dc.subject | randomization | en |
dc.subject | surgical mesh | en |
dc.subject | tissue adhesion | en |
dc.subject | treatment outcome | en |
dc.subject | Animals | en |
dc.subject | Dimethindene | en |
dc.subject | Drug Therapy, Combination | en |
dc.subject | Female | en |
dc.subject | Icodextrin | en |
dc.subject | Injections, Intramuscular | en |
dc.subject | Injections, Intraperitoneal | en |
dc.subject | Injections, Intravenous | en |
dc.subject | Polypropylenes | en |
dc.subject | Postoperative Complications | en |
dc.subject | Protective Agents | en |
dc.subject | Rabbits | en |
dc.subject | Random Allocation | en |
dc.subject | Surgical Mesh | en |
dc.subject | Tissue Adhesions | en |
dc.subject | Treatment Outcome | en |
dc.subject | Academic Press Inc. | en |
dc.title | Adhesion Prevention to Polypropylene Meshes Using Combined Icodextrin Four Percent and Dimetindene Maleate | en |
dc.type | journalArticle | en |