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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
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ICAM-1, ICAM-2 and ICAM-3 in the sera of patients with idiopathic pulmonary fibrosis

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Author
Tsoutsou, P. G.; Gourgoulianis, K. I.; Petinaki, E.; Mpaka, M.; Efremidou, S.; Maniatis, A.; Molyvdas, P. A.
Date
2004
DOI
10.1007/s10753-004-6647-6
Keyword
Cell adhesion molecules
Idiopathic pulmonary fibrosis
Interstitial lung disease
intercellular adhesion molecule 1
intercellular adhesion molecule 2
intercellular adhesion molecule 3
adult
aged
article
blood level
clinical article
controlled study
disease association
enzyme linked immunosorbent assay
female
fibrosing alveolitis
human
idiopathic disease
lung fibrosis
lung function test
male
volunteer
Antigens, CD
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Humans
Intercellular Adhesion Molecule-1
Prospective Studies
Pulmonary Fibrosis
Metadata display
Abstract
In order to test the serum levels of ICAM-1, ICAM-2 and ICAM-3 in patients with idiopathic pulmonary fibrosis (IPF), twenty patients with IPF and eleven with secondary interstitial fibrosis (SIF), as well as forty healthy volunteers (HV) were studied. Serum intracellular adhesion molecules (ICAM) 1, 2 and 3 were assessed by ELISA. Functional respiratory tests, which included spirometry and lung diffusing capacity were simultaneously performed. Median values of serum ICAM-1 and ICAM-2 were higher in the patients' than in the healthy volunteers' (HV) group: IPF group: 946.60 ng/ml and 400.14 ng/ml; SIF group: 901.58 ng/ml and 378.27 ng/ml; HV group: 308.40 ng/ml and 217.55 ng/ml, respectively (p < 0.05). ICAM-3 serum levels were equal between the three groups. ICAM-2 negatively correlated to DLCO values. (p < 0.005). It can be concluded that ICAM 1 and 2 are elevated in the sera of patients with pulmonary fibrosis. ICAM-2 might be associated with a more impaired clinical status. © Springer Science+Business Media, Inc.
URI
http://hdl.handle.net/11615/34094
Collections
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19705]

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