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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Analysis of the quality of reporting of randomized controlled trials in anticoagulant versus antiplatelet medication for venous thromboembolism prophylaxis as governed by the CONSORT statement

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Author
Beneki E., Vrysis C., Zintzaras E., Doxani C.
Date
2021
Language
en
DOI
10.1007/s11239-020-02315-0
Keyword
acetylsalicylic acid
anticoagulant agent
antithrombocytic agent
apixaban
clopidogrel
edoxaban
heparin
low molecular weight heparin
prasugrel
rivaroxaban
warfarin
anticoagulant agent
antithrombocytic agent
acute coronary syndrome
anticoagulant therapy
antiplatelet activity
atrial fibrillation
blood clotting time
checklist
clinical assessment
comparative study
controlled study
follow up
human
lung embolism
medication compliance
outcome assessment
percutaneous coronary intervention
qualitative analysis
quality control
questionnaire
randomized controlled trial
Review
sample size
secondary prevention
thrombocyte aggregation
thrombosis prevention
validity
venous thromboembolism
lung embolism
randomized controlled trial (topic)
vein thrombosis
venous thromboembolism
Anticoagulants
Humans
Platelet Aggregation Inhibitors
Pulmonary Embolism
Randomized Controlled Trials as Topic
Venous Thromboembolism
Venous Thrombosis
Springer
Metadata display
Abstract
Randomized controlled trials (RCTs) are the gold standard research in evaluating healthcare interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement improves the quality of RCTs in an evidence-based approach. To evaluate the reporting quality of published RCTs concerning the use of anticoagulants versus antiplatelet agents for venous thromboembolism prophylaxis according to the CONSORT statement. Electronic databases were searched for English-language RCTs involving patients who received either anticoagulant or antiplatelet medication for prophylaxis of deep vein thrombosis and pulmonary embolism published from 2000 to 2019. Trials were considered eligible when the included patients received either anticoagulant or antiplatelet medication for primary and secondary prevention of deep vein thrombosis or pulmonary embolism and were randomly assigned to at least two treatment arms. Quality of reporting was assessed using a 37-item questionnaire based on the CONSORT 2010 checklist. Reporting was assessed in 2 publication periods (2000–2009) and (2010–2019). The effect of CONSORT statement in high- and low-ranked medical journals, according to their impact factor, has also been evaluated. The search identified 13 eligible articles for analysis. Only 12 of the 37 items of the checklist were addressed in 75% or more of the studies. Most items concerning the methodological issues were reported by fewer than 50% of the studies. Improvements over time were seen for items that assessed the methodological quality with no statistically significant difference. RCTs published in high-ranked journals showed better quality of reporting. Quality of reporting in RCTs focusing on the use of anticoagulants versus antiplatelet agents for venous thromboembolism prophylaxis remains unsatisfactory. Further improvement of reporting is necessary to assess the validity of clinical research. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
URI
http://hdl.handle.net/11615/71567
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19705]

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