Therapy with proton-pump inhibitors for gastroesophageal reflux disease does not reduce the risk for severe exacerbations in COPD

Baumeler L., Papakonstantinou E., Milenkovic B., Lacoma A., Louis R., Aerts J.G., Welte T., Kostikas K., Blasi F., Boersma W., Torres A., Rohde G.G.U., Boeck L., Rakic J., Scherr A., Tamm M., Stolz D.

Συγγραφέας

Baumeler L., Papakonstantinou E., Milenkovic B., Lacoma A., Louis R., Aerts J.G., Welte T., Kostikas K., Blasi F., Boersma W., Torres A., Rohde G.G.U., Boeck L., Rakic J., Scherr A., Tamm M., Stolz D.

Ημερομηνία

2016

Γλώσσα

DOI

10.1111/resp.12758

Εμφάνιση Μεταδεδομένων

Επιτομή

Background and objective: Gastroesophageal reflux disease (GERD) symptoms are associated with a higher risk of chronic obstructive pulmonary disease (COPD) exacerbation. We hypothesize that treatment with proton pump inhibitors reduces the risk of exacerbation in patients with stable COPD. Methods: A total of 638 patients with stable COPD for ≥6 weeks, ≥10 pack-years of smoking and Global Initiative for Chronic Obstructive Lung Disease II–IV seeking care in tertiary hospitals in eight European countries in the Predicting Outcome using Systemic Markers in Severe Exacerbations-COPD cohort was prospectively evaluated by us. Comorbidities including associated medical treatment were assessed at baseline, at exacerbation and at biannual visits. Median observation time was 24 months. The primary study outcomes were exacerbation and/or death. Results: A total of 85 (13.3%) of COPD patients were on anti-GERD therapy. These patients had higher annual and higher severe exacerbation rates (P = 0.009 and P = 0.002), decreased quality of life (SF-36: activity score P = 0.004, St. George's Respiratory Questionnaire: physical functioning P = 0.013 and social functioning P = 0.007), higher body mass airflow obstruction, dyspnea and exercise capacity index (P = 0.033) and Modified Medical Research Council scores (P = 0.002), shorter 6-min walking distance (P = 0.0004) and a higher adjusted Charlson score (P < 0.0001). Anti-GERD therapy was associated with a shorter time to severe exacerbation (HR 2.05 95% CI 1.37–3.08). Using three multivariable Cox-regression models, this association was independent of the following: (i) adjusted Charlson score and FEV1% predicted (HR 1.91 95% CI 1.26–2.90); (ii) adjusted Charlson score, body mass, airflow obstruction, dyspnea and exercise capacity index and Modified Medical Research Council (HR 1.62 95% CI 1.04–2.54); and (iii) adjusted Charlson score, FEV1% predicted and nine classes of medication for comorbidities (HR 1.63 95% CI 1.04–2.53). Conclusion: These findings suggest that patients with stable COPD receiving acid-suppressive therapy with proton pump inhibitors remain at high risk of frequent and severe exacerbations. © 2016 Asian Pacific Society of Respirology

URI

http://hdl.handle.net/11615/71191

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Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19735]

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Global, regional, and national age-sex specifc mortality for 264 causes of death, 1980-2016: A systematic analysis for the Global Burden of Disease Study 2016

Naghavi M., Abajobir A.A., Abbafati C., Abbas K.M., Abd-Allah F., Abera S.F., Aboyans V., Adetokunboh O., Ärnlöv J., Afshin A., Agrawal A., Kiadaliri A.A., Ahmadi A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Al-Eyadhy A., Alahdab F., Al-Aly Z., Alam K., Alam N., Alam T., Alene K.A., Ali S.D., Alizadeh-Navaei R., Alkaabi J.M., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Raddadi R., Alsharif U., Altirkawi K.A., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Amoako Y.A., Anber N., Andersen H.H., Andrei C.L., Androudi S., Ansari H., Antonio C.A.T., Anwari P., Arora M., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Atey T.M., Avila-Burgos L., Avokpaho E.F.G.A., Awasthi A., Quintanilla B.P.A., Béjot Y., Babalola T.K., Bacha U., Balakrishnan K., Barac A., Barboza M.A., Barker-Collo S.L., Barquera S., Barregard L., Barrero L.H., Baune B.T., Bedi N., Beghi E., Bekele B.B., Bell M.L., Bennett J.R., Bensenor I.M., Berhane A., Bernabé E., Betsu B.D., Beuran M., Bhatt S., Biadgilign S., Bienhof K., Bikbov B., Bisanzio D., Bourne R.R.A., Breitborde N.J.K., Bulto L.N.B., Bumgarner B.R., Butt Z.A., Cárdenas R., Cahuana-Hurtado L., Cameron E., Campuzano J.C., Car J., Carrero J.J., Carter A., Casey D.C., Castañeda-Orjuela C.A., Catalá-López F., Charlson F.J., Chibueze C.E., Chimed-Ochir O., Chisumpa V.H., Chitheer A.A., Christopher D.J., Ciobanu L.G., Cirillo M., Cohen A.J., Colombara D., Cooper C., Cowie B.C., Criqui M.H., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davitoiu D.V., Davletov K., De Courten B., Degenhardt L., Deiparine S., Deribe K., Deribew A., Dey S., Dicker D., Ding E.L., Djalalinia S., Do H.P., Doku D.T., Douwes-Schultz D., Driscoll T.R., Dubey M., Duncan B.B., Echko M., El-Khatib Z.Z., Ellingsen C.L., Enayati A., Erskine H.E., Eskandarieh S., Esteghamati A., Ermakov S.P., Estep K., Sa Farinha C.S., Faro A., Farzadfar F., Feigin V.L., Fereshtehnejad S.-M., Fernandes J.C., Ferrari A.J., Feyissa T.R., Filip I., Finegold S., Fischer F., Fitzmaurice C., Flaxman A.D., Foigt N., Frank T., Fraser M., Fullman N., Fürst T., Furtado J.M., Gakidou E., Garcia-Basteiro A.L., Gebre T., Gebregergs G.B., Gebrehiwot T.T., Gebremichael D.Y., Geleijnse J.M., Genova-Maleras R., Gesesew H.A., Gething P.W., Gillum R.F., Ginawi I.A.M., Giref A.Z., Giroud M., Giussani G., Godwin W.W., Gold A.L., Goldberg E.M., Gona P.N., Gopalani S.V., Gouda H.N., Goulart A.C., Griswold M., Gupta P.C., Gupta R., Gupta T., Gupta V., Haagsma J.A., Hafezi-Nejad N., Hailu A.D., Hailu G.B., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hancock J., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Hassanvand M.S., Havmoeller R., Hay S.I., He F., Hedayati M.T., Henry N.J., Heredia-Pi I.B., Herteliu C., Hoek H.W., Horino M., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Huynh C., Iburg K.M., Ikeda C., Ileanu B.V., Irenso A.A., Irvine C.M.S., Jürisson M., Jacobsen K.H., Jahanmehr N., Jakovljevic M.B., Javanbakht M., Jayaraman S.P., Jeemon P., Jha V., John D., Johnson C.O., Johnson S.C., Jonas J.B., Kabir Z., Kadel R., Kahsay A., Kamal R., Karch A., Karimi S.M., Karimkhani C., Kasaeian A., Kassaw N.A., Kassebaum N.J., Katikireddi S.V., Kawakami N., Keiyoro P.N., Kemmer L., Kesavachandran C.N., Khader Y.S., Khan E.A., Khang Y.-H., Khoja A.T.A., Khosravi A., Khosravi M.H., Khubchandani J., Kieling C., Kievlan D., Kim D., Kim Y.J., Kimokoti R.W., Kinfu Y., Kissoon N., Kivimaki M., Knudsen A.K., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Defo B.K., Kulikof X.R., Kumar G.A., Kumar P., Kutz M., Kyu H.H., Lal D.K., Lalloo R., Lambert T.L.N., Lan Q., Lansingh V.C., Larsson A., Lee P.H., Leigh J., Leung J., Levi M., Li Y., Kappe D.L., Liang X., Liben M.L., Lim S.S., Liu A., Liu P.Y., Liu Y., Lodha R., Logroscino G., Lorkowski S., Lotufo P.A., Lozano R., Lucas T.C.D., Ma S., Macarayan E.R.K., Maddison E.R., Abd El Razek M.M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Manguerra H., Manyazewal T., Mapoma C.C., Marczak L.B., Markos D., Martinez-Raga J., Martins-Melo F.R., Martopullo I., McAlinden C., McGaughey M., McGrath J.J., Mehata S., Meier T., Meles K.G., Memiah P., Memish Z.A., Mengesha M.M., Mengistu D.T., Menota B.G., Mensah G.A., Meretoja A., Meretoja T.J., Millear A., Miller T.R., Minnig S., Mirarefn M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mohammad K.A., Mohammadi A., Mohammed S., Mokdad A.H., Mola G.L.D., Mollenkopf S.K., Molokhia M., Monasta L., Hernandez J.C.M., Montico M., Mooney M.D., Moradi-Lakeh M., Moraga P., Morawska L., Morrison S.D., Morozof C., Mountjoy-Venning C., Mruts K.B., Muller K., Murthy G.V.S., Musa K.I., Nachega J.B., Naheed A., Naldi L., Nangia V., Nascimento B.R., Nasher J.T., Natarajan G., Negoi I., Ngunjiri J.W., Nguyen C.T., Nguyen G., Nguyen M., Nguyen Q.L., Nguyen T.H., Nichols E., Ningrum D.N.A., Nong V.M., Noubiap J.J.N., Ogbo F.A., Oh I.-H., Okoro A., Olagunju A.T., Olsen H.E., Olusanya B.O., Olusanya J.O., Ong K., Opio J.N., Oren E., Ortiz A., Osman M., Ota E., Mahesh P.A., Pacella R.E., Pakhale S., Pana A., Panda B.K., Jonas S., Papachristou C., Park E.-K., Patten S.B., Patton G.C., Paudel D., Paulson K., Pereira D.M., Perez-Ruiz F., Perico N., Pervaiz A., Petzold M., Phillips M.R., Pigott D.M., Pinho C., Plass D., Pletcher M.A., Polinder S., Postma M.J., Pourmalek F., Purcell C., Qorbani M., Radfar A., Rafay A., Rahimi-Movaghar V., Rahman M., Ur Rahman M.H., Rai R.K., Ranabhat C.L., Rankin Z., Rao P.C., Rath G.K., Rawaf S., Ray S.E., Rehm J., Reiner R.C., Reitsma M.B., Remuzzi G., Rezaei S., Rezai M.S., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Ruhago G.M., Rizwan S.A., Saadat S., Sachdev P.S., Sadat N., Safdarian M., Saf S., Safiri S., Sagar R., Sahathevan R., Salama J., Salamati P., Salomon J.A., Samy A.M., Sanabria J.R., Sanchez-Niño M.D., Santomauro D., Santos I.S., Milicevic M.M.S., Sartorius B., Satpathy M., Shahraz S., Schmidt M.I., Schneider I.J.C., Schulhofer-Wohl S., Schutte A.E., Schwebel D.C., Schwendicke F., Sepanlou S.G., Servan-Mori E.E., Shackelford K.A., Shaikh M.A., Shamsipour M., Shamsizadeh M., Islam S.M.S., Sharma J., Sharma R., She J., Sheikhbahaei S., Shey M., Shi P., Shields C., Shigematsu M., Shiri R., Shirude S., Shiue I., Shoman H., Shrime M.G., Sigfusdottir I.D., Silpakit N., Silva J.P., Singh A., Singh J.A., Skiadaresi E., Sligar A., Smith A., Smith D.L., Smith M., Sobaih B.H.A., Soneji S., Sorensen R.J.D., Soriano J.B., Sreeramareddy C.T., Srinivasan V., Stanaway J.D., Stathopoulou V., Steel N., Stein D.J., Steiner C., Steinke S., Stokes M.A., Strong M., Strub B., Subart M., Sufyan M.B., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Tabarés-Seisdedos R., Tadakamadla S.K., Takahashi K., Takala J.S., Talongwa R.T., Tarawneh M.R., Tavakkoli M., Taveira N., Tegegne T.K., Tehrani-Banihashemi A., Temsah M.-H., Terkawi A.S., Thakur J.S., Thamsuwan O., Thankappan K.R., Thomas K.E., Thompson A.H., Thomson A.J., Thrift A.G., Tobe-Gai R., Topor-Madry R., Torre A., Tortajada M., Towbin J.A., Tran B.X., Troeger C., Truelsen T., Tsoi D., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Updike R., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Vasankari T., Venketasubramanian N., Violante F.S., Vlassov V.V., Vollset S.E., Vos T., Wakayo T., Wallin M.T., Wang Y.-P., Weiderpass E., Weintraub R.G., Weiss D.J., Werdecker A., Westerman R., Whetter B., Whiteford H.A., Wijeratne T., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Woodbrook R., Workicho A., Xavier D., Xiao Q., Xu G., Yaghoubi M., Yakob B., Yano Y., Yaseri M., Yimam H.H., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., El Sayed Zaki M., Zegeye E.A., Zenebe Z.M., Zerfu T.A., Zhang A.L., Zhang X., Zipkin B., Zodpey S., Lopez A.D., Murray C.J.L., GBD 2016 Causes of Death Collaborators (2017)

Background: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive ...
Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: A novel analysis from the global burden of disease study 2015

Barber R.M., Fullman N., Sorensen R.J.D., Bollyky T., McKee M., Nolte E., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abdurahman A.A., Abera S.F., Abraham B., Abreha G.F., Adane K., Adelekan A.L., Adetifa I.M.O., Afshin A., Agarwal A., Agarwal S.K., Agarwal S., Agrawal A., Ahmad Kiadaliri A., Ahmadi A., Ahmed K.Y., Ahmed M.B., Akinyemi R.O., Akinyemiju T.F., Akseer N., Al-Aly Z., Alam K., Alam N., Alam S.S., Alemu Z.A., Alene K.A., Alexander L., Ali R., Ali S.D., Alizadeh-Navaei R., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Raddadi R., Alsharif U., Altirkawi K.A., Alvarez Martin E., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Amo-Adjei J., Amoako Y.A., Anderson B.O., Androudi S., Ansari H., Ansha M.G., Antonio C.A.T., Ärnlöv J., Artaman A., Asayesh H., Assadi R., Astatkie A., Atey T.M., Atique S., Atnafu N.T., Atre S.R., Avila-Burgos L., Avokpaho E.F.G.A., Ayala Quintanilla B.P., Awasthi A., Ayele N.N., Azzopardi P., Ba Saleem H.O., Bärnighausen T., Bacha U., Badawi A., Banerjee A., Barac A., Barboza M.A., Barker-Collo S.L., Barrero L.H., Basu S., Baune B.T., Baye K., Bayou Y.T., Bazargan-Hejazi S., Bedi N., Beghi E., Béjot Y., Bello A.K., Bennett D.A., Bensenor I.M., Berhane A., Bernabé E., Bernal O.A., Beyene A.S., Beyene T.J., Bhutta Z.A., Biadgilign S., Bikbov B., Birlik S.M., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Bose D., Brainin M., Brauer M., Brazinova A., Breitborde N.J.K., Brenner H., Butt Z.A., Cárdenas R., Cahuana-Hurtado L., Campos-Nonato I.R., Car J., Carrero J.J., Casey D., Caso V., Castañeda-Orjuela C.A., Castillo Rivas J., Catalá-López F., Cecilio P., Cercy K., Charlson F.J., Chen A.Z., Chew A., Chibalabala M., Chibueze C.E., Chisumpa V.H., Chitheer A.A., Chowdhury R., Christensen H., Christopher D.J., Ciobanu L.G., Cirillo M., Coggeshall M.S., Cooper L.T., Cortinovis M., Crump J.A., Dalal K., Danawi H., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davey G., Davitoiu D.V., Davletov K., De Leo D., Del Gobbo L.C., Del Pozo-Cruz B., Dellavalle R.P., Deribe K., Deribew A., Des Jarlais D.C., Dey S., Dharmaratne S.D., Dicker D., Ding E.L., Dokova K., Dorsey E.R., Doyle K.E., Dubey M., Ehrenkranz R., Ellingsen C.L., Elyazar I., Enayati A., Ermakov S.P., Eshrati B., Esteghamati A., Estep K., Fürst T., Faghmous I.D.A., Fanuel F.B.B., Faraon E.J.A., Farid T.A., Farinha C.S.E.S., Faro A., Farvid M.S., Farzadfar F., Feigin V.L., Feigl A.B., Fereshtehnejad S.-M., Fernandes J.G., Fernandes J.C., Feyissa T.R., Fischer F., Fitzmaurice C., Fleming T.D., Foigt N., Foreman K.J., Forouzanfar M.H., Franklin R.C., Frostad J., Ghiwot T.T., Gakidou E., Gambashidze K., Gamkrelidze A., Gao W., Garcia-Basteiro A.L., Gebre T., Gebremedhin A.T., Gebremichael M.W., Gebru A.A., Gelaye A.A., Geleijnse J.M., Genova-Maleras R., Gibney K.B., Giref A.Z., Gishu M.D., Giussani G., Godwin W.W., Gold A., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goto A., Graetz N., Greaves F., Griswold M., Guban P.I., Gugnani H.C., Gupta P.C., Gupta R., Gupta R., Gupta T., Gupta V., Habtewold T.D., Hafezi-Nejad N., Haile D., Hailu A.D., Hailu G.B., Hakuzimana A., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Hassanvand M.S., Havmoeller R., Hay R.J., Hay S.I., Hendrie D., Heredia-Pi I.B., Hoek H.W., Horino M., Horita N., Hosgood H.D., Htet A.S., Hu G., Huang H., Huang J.J., Huntley B.M., Huynh C., Iburg K.M., Ileanu B.V., Innos K., Irenso A.A., Jahanmehr N., Jakovljevic M.B., James P., James S.L., Javanbakht M., Jayaraman S.P., Jayatilleke A.U., Jeemon P., Jha V., John D., Johnson C., Johnson S.C., Jonas J.B., Juel K., Kabir Z., Kalkonde Y., Kamal R., Kan H., Karch A., Karema C.K., Karimi S.M., Kasaeian A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kazanjan K., Keiyoro P.N., Kemmer L., Kemp A.H., Kengne A.P., Kerbo A.A., Kereselidze M., Kesavachandran C.N., Khader Y.S., Khalil I., Khan A.R., Khan E.A., Khan G., Khang Y.-H., Khoja A.T.A., Khonelidze I., Khubchandani J., Kibret G.D., Kim D., Kim P., Kim Y.J., Kimokoti R.W., Kinfu Y., Kissoon N., Kivipelto M., Kokubo Y., Kolk A., Kolte D., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krishnaswami S., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kuipers E.J., Kulkarni V.S., Kumar G.A., Kumsa F.A., Kutz M., Kyu H.H., Lager A.C.J., Lal A., Lal D.K., Lalloo R., Lallukka T., Lan Q., Langan S.M., Lansingh V.C., Larson H.J., Larsson A., Laryea D.O., Latif A.A., Lawrynowicz A.E.B., Leasher J.L., Leigh J., Leinsalu M., Leshargie C.T., Leung J., Leung R., Levi M., Liang X., Lim S.S., Lind M., Linn S., Lipshultz S.E., Liu P., Liu Y., Lo L.-T., Logroscino G., Lopez A.D., Lorch S.A., Lotufo P.A., Lozano R., Lunevicius R., Lyons R.A., Macarayan E.R.K., Mackay M.T., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahdavi M., Majeed A., Malekzadeh R., Malta D.C., Mantovani L.G., Manyazewal T., Mapoma C.C., Marcenes W., Marks G.B., Marquez N., Martinez-Raga J., Marzan M.B., Massano J., Mathur M.R., Maulik P.K., Mazidi M., McAlinden C., McGrath J.J., McNellan C., Meaney P.A., Mehari A., Mehndiratta M.M., Meier T., Mekonnen A.B., Meles K.G., Memish Z.A., Mengesha M.M., Mengiste D.T., Mengistie M.A., Menota B.G., Mensah G.A., Mereta S.T., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Mills E.J., Minnig S., Mirarefin M., Mirrakhimov E.M., Mock C.N., Mohammad K.A., Mohammed S., Mohanty S.K., Mokdad A.H., Mola G.L.D., Molokhia M., Monasta L., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Mori R., Moses M., Mueller U.O., Murthy S., Musa K.I., Nachega J.B., Nagata C., Nagel G., Naghavi M., Naheed A., Naldi L., Nangia V., Nascimento B.R., Negoi I., Neupane S.P., Newton C.R., Ng M., Ngalesoni F.N., Ngunjiri J.W., Nguyen G., Ningrum D.N.A., Nolte S., Nomura M., Norheim O.F., Norrving B., Noubiap J.J.N., Obermeyer C.M., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olivares P.R., Olsen H.E., Olusanya B.O., Olusanya J.O., Opio J.N., Oren E., Ortiz A., Osborne R.H., Osman M., Owolabi M.O., Mahesh P.A., Pain A.W., Pakhale S., Palomares Castillo E., Pana A., Papachristou C., Parsaeian M., Patel T., Patton G.C., Paudel D., Paul V.K., Pearce N., Pereira D.M., Perez-Padilla R., Perez-Ruiz F., Perico N., Pesudovs K., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Polinder S., Pond C.D., Prakash V., Purwar M., Qorbani M., Quistberg D.A., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rai R.K., Ram U., Rana S.M., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Rego M.A.S., Reitsma M., Remuzzi G., Renzaho A.M.N.N., Resnikoff S., Rezaei S., Rezai M.S., Ribeiro A.L., Roba H.S., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Roy N.K., Sachdev P.S., Sackey B.B., Saeedi M.Y., Safiri S., Sagar R., Sahraian M.A., Saleh M.M., Salomon J.A., Samy A.M., Sanabria J.R., Sanchez-Niño M.D., Sandar L., Santos I.S., Santos J.V., Santric Milicevic M.M., Sarmiento-Suarez R., Sartorius B., Satpathy M., Savic M., Sawhney M., Saylan M.I., Schöttker B., Schutte A.E., Schwebel D.C., Seedat S., Seid A.M., Seifu C.N., Sepanlou S.G., Serdar B., Servan-Mori E.E., Setegn T., Shackelford K.A., Shaheen A., Shahraz S., Shaikh M.A., Shakh-Nazarova M., Shamsipour M., Shariful Islam S.M., Sharma J., Sharma R., She J., Sheikhbahaei S., Shen J., Shi P., Shigematsu M., Shin M.-J., Shiri R., Shoman H., Shrime M.G., Sibamo E.L.S., Sigfusdottir I.D., Silva D.A.S., Silveira D.G.A., Sindi S., Singh A., Singh J.A., Singh O.P., Singh P.K., Singh V., Sinke A.H., Sinshaw A.E., Skirbekk V., Sliwa K., Smith A., Sobngwi E., Soneji S., Soriano J.B., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Stathopoulou V., Steel N., Steiner C., Steinke S., Stokes M.A., Stranges S., Strong M., Stroumpoulis K., Sturua L., Sufiyan M.B., Suliankatchi R.A., Sun J., Sur P., Swaminathan S., Sykes B.L., Tabarés-Seisdedos R., Tabb K.M., Taffere G.R., Talongwa R.T., Tarajia M., Tavakkoli M., Taveira N., Teeple S., Tegegne T.K., Tehrani-Banihashemi A., Tekelab T., Tekle D.Y., Temam Shifa G., Terkawi A.S., Tesema A.G., Thakur J.S., Thomson A.J., Tillmann T., Tiruye T.Y., Tobe-Gai R., Tonelli M., Topor-Madry R., Tortajada M., Troeger C., Truelsen T., Tura A.K., Uchendu U.S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Uthman O.A., Van Boven J.F.M., Van Dingenen R., Varughese S., Vasankari T., Venketasubramanian N., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wagner J.A., Wakayo T., Waller S.G., Walson J.L., Wang H., Wang Y.-P., Watkins D.A., Weiderpass E., Weintraub R.G., Wen C.-P., Werdecker A., Wesana J., Westerman R., Whiteford H.A., Wilkinson J.D., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Won S., Workicho A., Workie S.B., Wubshet M., Xavier D., Xu G., Yadav A.K., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Yaseri M., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Younis M.Z., Yu C., Zaidi Z., El Sayed Zaki M., Zambrana-Torrelio C., Zapata T., Zenebe Z.M., Zodpey S., Zoeckler L., Zuhlke L.J., Murray C.J.L., GBD 2015 Healthcare Access and Quality Collaborators (2017)

Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). ...
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19

Tsatsakis A., Calina D., Falzone L., Petrakis D., Mitrut R., Siokas V., Pennisi M., Lanza G., Libra M., Doukas S.G., Doukas P.G., Kavali L., Bukhari A., Gadiparthi C., Vageli D.P., Kofteridis D.P., Spandidos D.A., Paoliello M.M.B., Aschner M., Docea A.O. (2020)

Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to severe acute respiratory distress. The severity of the illness can also extend from mild disease to life-threatening acute respiratory ...