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Bone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): The CUMAGAS-BMD information system

dc.creatorZintzaras, E.en
dc.creatorDoxani, C.en
dc.creatorZiogas, D. C.en
dc.creatorMprotsis, T.en
dc.creatorRodopoulou, P.en
dc.creatorKarachalios, T.en
dc.date.accessioned2015-11-23T10:55:09Z
dc.date.available2015-11-23T10:55:09Z
dc.date.issued2011
dc.identifier10.3109/1354750X.2011.629373
dc.identifier.issn1354750X
dc.identifier.urihttp://hdl.handle.net/11615/34942
dc.description.abstractThe focal adhesion, the actin cytoskeleton and cell-cycle are connected pathways and their genes are implicated in the pathogenesis of low BMD. Data from 211 studies that investigated the association between BMD and gene variants involved in these pathways were catalogued in a web-based information system and analyzed. In individual studies, significant association was found for 16 variants in lumbar spine, 11 in femoral neck and 5 in hip. In meta-analysis, significant results were shown for the variants COL1A1 rs1800012 (in lumbar spine and femoral neck), COL1A1 rs1107946 (in lumbar spine), TGFB1 rs1982073 (in femoral neck and hip) and TGFB1 rs1800469 (in lumbar spine). © 2011 Informa UK, Ltd.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-81855168355&partnerID=40&md5=d4fffacdb2fd01110aeb33fc5379c09e
dc.subjectActin cytoskeleton regulationen
dc.subjectBone mineral densityen
dc.subjectCell cycle pathwaysen
dc.subjectFocal adhesionen
dc.subjectGenetic polymorphismen
dc.subjectInformation systemen
dc.subjectMeta-analysisen
dc.subjectactinen
dc.subjectcollagen type 1en
dc.subjectcollagen type 1 alpha 1en
dc.subjecttransforming growth factor betaen
dc.subjectunclassified drugen
dc.subjectarticleen
dc.subjectbone densityen
dc.subjectcell cycleen
dc.subjectcytoskeletonen
dc.subjectfemur necken
dc.subjectgenetic associationen
dc.subjectgenetic markeren
dc.subjectgenetic variabilityen
dc.subjecthipen
dc.subjecthumanen
dc.subjectlumbar spineen
dc.titleBone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): The CUMAGAS-BMD information systemen
dc.typejournalArticleen


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