Leukotriene antagonists: As firstline asthmatic therapy: A review

Abstract

Asthma is a chronic inflammatory disorder characterized by airflow obstruction. The development of leukotriene receptor antagonists and synthesis inhibitors in briefly described; and acute exercise, allergen, and aspirin challenge, studies with these agents are reviewed. Clinical studies with leukotriene antagonists and inhibitors have confirmed the central role leukotrienes of in asthma. The new generation of leukotriene receptor antagonist may be suitable as first-line therapy in patients with mild to moderate asthma.