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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
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Study of insulin resistance, TNF-α, total antioxidant capacity and lipid profile in patients with chronic heart failure under exercise

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Author
Tsarouhas, K.; Tsitsimpikou, C.; Haliassos, A.; Georgoulias, P.; Koutsioras, I.; Kouretas, D.; Kogias, J.; Liosis, I.; Rentoukas, E.; Kyriakides, Z.
Date
2011
Keyword
Chronic heart failure
Insulin resistance
Lipids
TNF-α
Total antioxidant capacity
antioxidant
apolipoprotein A1
apolipoprotein B
high density lipoprotein
insulin
lipid
lipoprotein A
low density lipoprotein
triacylglycerol
tumor necrosis factor alpha
uric acid
aged
article
clinical article
controlled study
endothelium
exercise
female
glucose blood level
glucose metabolism
glycemic control
heart ejection fraction
heart failure
human
inflammation
insulin blood level
insulin sensitivity
lipid analysis
lipid metabolism
male
metabolic syndrome X
oxidative stress
physical activity
triacylglycerol blood level
uric acid blood level
walking
Antioxidants
Chronic Disease
Humans
Middle Aged
Patient Compliance
Tumor Necrosis Factors
Metadata display
Abstract
Gluco-metabolic syndrome, oxidative stress and inflammation are common in chronic heart failure (CHF). Exercise training programmes are known to improve oxidative status, insulin sensitivity and endothelial function. In this study, the effects of walking on improving lipid and glucose metabolism in CHF patients, under statin treatment, were investigated. Fasting glucose, serum insulin, tumor necrosis factor-α (TNF-α), total antioxidant capacity (TAC), uric acid (UA), total cholesterol, triglycerides, high-density lipoproteins (HDL), direct low-density lipoproteins (LDL-dir), apolipoprotein-B, apolipoprotein-A1, and lipoprotein-a (Lp(a)) were monitored. Insulin resistance was depicted by fasting insulin resistance index (FIRI) (FIRI≥2.94±1. 41). HDL significantly increased with walking and was positively correlated with the non-significant triglyceride decrease and significant Lp(a) decrease. Significant correlations were found in all CHF patients at baseline between FIRI and New York Heart Association (NYHA) functional class, ejection fraction, HDL, triglycerides and TNF-α. All non-diabetic CHF patients were characterized by insulin resistance. Serum insulin and fasting glucose significantly decreased with walking, while decrease in FIRI was positively associated with patients' adherence to the walking program. Elevated uric acid and TNF-α levels also significantly decreased. In conclusion, the present study demonstrated that moderate, unsupervised, everyday physical activity was able to ameliorate the lipid and glycemic profile of CHF patients, with simultaneous attenuation of inflammation and oxidative stress.
URI
http://hdl.handle.net/11615/33820
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [9728]

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