Unraveling the link between leptin, ghrelin and different types of colitis
Data
2011Soggetto
Abstract
Leptin and ghrelin are hormones with a tight inverse functional connection. Their inverse association is observed not only in the modulation of metabolism but also in the interaction with the immune system. A large number of studies have been launched regarding their association with various disorders, including different types of colitis. The majority of the available literature, however, focuses on inflammatory bowel disease. The role of leptin and ghrelin appears to be aggravating in most of these studies. Concerning intestinal infections, their levels seem to depend on the presence of certain species of micro-biota. As for models of ischemic and miscellaneous colitis, both hormones seem to act protectively, although evidence deriving from human studies is needed before any safe conclusions can be made. Conclusively, it seems that available data, from in vitro, animal and human studies, suggest of a multifarious role for leptin and ghrelin, in the face of different triggers, which in turn cause diverse types of colitis. Bearing this in mind, gaps and loose ends are detected in the associated literature to encourage further research through which the association of leptin and ghrelin with intestinal inflammation could be clarified and expanded so that other types of colitis could also be included. © 2011 Hellenic Society of Gastroenterology.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Oral adjuvant curcumin therapy for attaining clinical remission in ulcerative colitis: A systematic review and meta-analysis of randomized controlled trials
Grammatikopoulou M.G., Gkiouras K., Theodoridis X., Asteriou E., Forbes A., Bogdanos D.P. (2018)Curcumin has demonstrated anti-inflammatory properties and has been investigated as an adjuvant therapy of ulcerative colitis (UC). The scope of this study was to systematically review and meta-analyze the efficacy of oral ... -
Novel immunoassays for detection of CUZD1 autoantibodies in serum of patients with inflammatory bowel diseases
Farkona S., Soosaipillai A., Filippou P., Liaskos C., Bogdanos D.P., Diamandis E.P., Blasutig I.M. (2017)Pancreatic autoantibodies (PABs) are detected in patients with inflammatory bowel disease (IBD). Their prevalence is higher in Crohn's disease (CrD) than in ulcerative colitis (UC). Glycoprotein 2 (GP2) and, more recently, ... -
Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis
Polychronopoulou E., Lygoura V., Gatselis N.K., Dalekos G.N. (2017)Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ...