Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of hellenic origin
dc.creator | Stakias, N. | en |
dc.creator | Liakos, P. | en |
dc.creator | Tsiapali, E. | en |
dc.creator | Goutou, M. | en |
dc.creator | Koukoulis, G. N. | en |
dc.date.accessioned | 2015-11-23T10:48:28Z | |
dc.date.available | 2015-11-23T10:48:28Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1079-5006 | |
dc.identifier.uri | http://hdl.handle.net/11615/33336 | |
dc.description.abstract | Apolipoprotein E (ApoE), and especially its epsilon 4 isoform, is considered a risk factor predisposing to coronary heart disease. We hypothesized that the absence of epsilon 4 allele offers a better chance for longer life. So we compared the prevalence of ApoE genotypes in 80 healthy aged individuals (HAI) (> 80 years) and 391 Greek adults (median age 43 years) with ApoE genotype distribution consistent with the Hardy-Weinberg equilibrium (chi(2) = 5.93, p > .05). ApoE genotypes were comparable in both groups with the exception of E3/3 and E3/4, which were significantly higher (87.50% vs 75.99%, p = .025) and lower (5.00% vs 13.19%, p = .036), respectively, in HAI. The epsilon 2 and epsilon 3 allele frequencies were not different between the groups. The epsilon 4 allele was significantly less frequent in HAI compared to controls (3.1% vs 8.58%, p = .020). Our results indicate an unfavorable effect of 64 allele on longevity that may be attenuated by environmental and/or other genetic factors. | en |
dc.source.uri | <Go to ISI>://WOS:000243701300003 | |
dc.subject | CORONARY-HEART-DISEASE | en |
dc.subject | ISCHEMIC CEREBROVASCULAR-DISEASE | en |
dc.subject | E | en |
dc.subject | POLYMORPHISM | en |
dc.subject | CARDIOVASCULAR-DISEASE | en |
dc.subject | ALZHEIMERS-DISEASE | en |
dc.subject | MYOCARDIAL-INFARCTION | en |
dc.subject | GREEK POPULATION | en |
dc.subject | E PHENOTYPES | en |
dc.subject | E GENOTYPE | en |
dc.subject | ALLELES | en |
dc.subject | Geriatrics & Gerontology | en |
dc.subject | Gerontology | en |
dc.title | Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of hellenic origin | en |
dc.type | journalArticle | en |
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