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Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

dc.creatorSahpazidou, D.en
dc.creatorGeromichalos, G. D.en
dc.creatorStagos, D.en
dc.creatorApostolou, A.en
dc.creatorHaroutounian, S. A.en
dc.creatorTsatsakis, A. M.en
dc.creatorTzanakakis, G. N.en
dc.creatorHayes, A. W.en
dc.creatorKouretas, D.en
dc.date.accessioned2015-11-23T10:46:45Z
dc.date.available2015-11-23T10:46:45Z
dc.date.issued2014
dc.identifier10.1016/j.toxlet.2014.01.042
dc.identifier.issn3784274
dc.identifier.urihttp://hdl.handle.net/11615/32763
dc.description.abstractA major part of the wineries' wastes is composed of grape stems which are discarded mainly in open fields and cause environmental problems due mainly to their high polyphenolic content. The grape stem extracts' use as a source of high added value polyphenols presents great interest because this combines a profitable venture with environmental protection close to wine-producing zones. In the present study, at first, the Total Polyphenolic Content (TPC) and the polyphenolic composition of grape stem extracts from four different Greek Vitis vinifera varieties were determined by HPLC methods. Afterwards, the grape stem extracts were examined for their ability to inhibit growth of colon (HT29), breast (MCF-7 and MDA-MB-23), renal (786-0 and Caki-1) and thyroid (K1) cancer cells. The cancer cells were exposed to the extracts for 72h and the effects on cell growth were evaluated using the SRB assay. The results indicated that all extracts inhibited cell proliferation, with IC50 values of 121-230μg/ml (MCF-7), 121-184μg/ml (MDA-MD-23), 175-309μg/ml (HT29), 159-314μg/ml (K1), 180-225μg/ml (786-0) and 134->400μg/ml (Caki-1). This is the first study presenting the inhibitory activity of grape stem extracts against growth of colon, breast, renal and thyroid cancer cells. © 2014 Elsevier Ireland Ltd.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84907171555&partnerID=40&md5=ec2d8d67ad66baabef5b2176180f1fae
dc.subjectAnticancer activityen
dc.subjectGrape stem extractsen
dc.subjectPolyphenolsen
dc.subjectVitis viniferaen
dc.subjectgrape stem extracten
dc.subjectplant extracten
dc.subjectpolyphenolen
dc.subjectunclassified drugen
dc.subjectantineoplastic agenten
dc.subjectantineoplastic activityen
dc.subjectArticleen
dc.subjectbreast canceren
dc.subjectcancer cellen
dc.subjectcancer inhibitionen
dc.subjectcell proliferationen
dc.subjectcolon canceren
dc.subjectcytotoxicityen
dc.subjectenvironmental protectionen
dc.subjectgrapeen
dc.subjecthigh performance liquid chromatographyen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjectIC50en
dc.subjectkidney canceren
dc.subjectplant stemen
dc.subjectthyroid canceren
dc.subjectBreast Neoplasmsen
dc.subjectColonic Neoplasmsen
dc.subjectKidney Neoplasmsen
dc.subjectpathologyen
dc.subjectThyroid Neoplasmsen
dc.subjecttumor cell lineen
dc.subjectVitisen
dc.subjectAnticarcinogenic Agentsen
dc.subjectCell Line, Tumoren
dc.subjectHumansen
dc.subjectPlant Extractsen
dc.subjectPlant Stemsen
dc.titleAnticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cellsen
dc.typejournalArticleen


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