Weaker synaptic inhibition in CA1 region of ventral compared to dorsal rat hippocampal slices
dc.creator | Papatheodoropoulos, C. | en |
dc.creator | Asprodini, E. | en |
dc.creator | Nikita, I. | en |
dc.creator | Koutsona, C. | en |
dc.creator | Kostopoulos, G. | en |
dc.date.accessioned | 2015-11-23T10:44:29Z | |
dc.date.available | 2015-11-23T10:44:29Z | |
dc.date.issued | 2002 | |
dc.identifier | 10.1016/s0006-8993(02)02958-x | |
dc.identifier.issn | 0006-8993 | |
dc.identifier.uri | http://hdl.handle.net/11615/31951 | |
dc.description.abstract | Extracellular and intracellular recordings were made from slices taken from the dorsal (DH) and ventral (VH) part of rat hippocampus. Using paired-pulse stimulation of Schaffer collaterals, at different interpulse intervals (IPIs), and records of the population spike (PS) we found that the strength and duration of paired-pulse inhibition was much weaker in VH compared to DH slices: at the IPI of 10 ms the decrease of PS in VH (40%) was significantly smaller compared to that in DH slices (76%), while at 20 ms the decrease of PS in DH slices (60%) corresponded to facilitation in VH slices. Moreover, the amplitude and duration of intracellularly recorded fast inhibitory postsynaptic potentials (fast-IPSPs) were found significantly smaller in VH (5.2+/-0.6 mV, 54.8+/-5.8 ms) than in DH (11.2+/-1.1 mV, 105+/-10 ms) neurons. The smaller and shorter fast-IPSP recorded in VH neurons may at least in part explain the results in paired-pulse inhibition. The demonstrated weaker inhibition may underlie the higher propensity of the ventral hippocampus for epileptiform activity. (C) 2002 Elsevier Science BY All rights reserved. | en |
dc.source | Brain Research | en |
dc.source.uri | <Go to ISI>://WOS:000178315000014 | |
dc.subject | ventral hippocampus | en |
dc.subject | septotemporal | en |
dc.subject | paired-pulse | en |
dc.subject | inhibition | en |
dc.subject | inhibitory | en |
dc.subject | postsynaptic potential | en |
dc.subject | GABA | en |
dc.subject | in vitro | en |
dc.subject | PYRAMIDAL CELLS | en |
dc.subject | GABAERGIC INHIBITION | en |
dc.subject | EPILEPSY | en |
dc.subject | INVITRO | en |
dc.subject | DISCHARGES | en |
dc.subject | Neurosciences | en |
dc.title | Weaker synaptic inhibition in CA1 region of ventral compared to dorsal rat hippocampal slices | en |
dc.type | journalArticle | en |
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