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Role of immunohistochemistry for hepatitis D and hepatitis B virus in hepatitis delta

dc.creatorKabaçam, G.en
dc.creatorWedemeyer, H.en
dc.creatorSavaş, B.en
dc.creatorKeskin, O.en
dc.creatorDalekos, G.en
dc.creatorTabak, F.en
dc.creatorIdilman, R.en
dc.creatorErhardt, A.en
dc.creatorYalçin, K.en
dc.creatorBozdayi, M. A.en
dc.creatorBozkaya, H.en
dc.creatorManns, M.en
dc.creatorDienes, H.en
dc.creatorYurdaydin, C.en
dc.creatorBerg, T.en
dc.creatorBöcher, W.en
dc.creatorBohle, H.en
dc.creatorBuggisch, P.en
dc.creatorCornberg, M.en
dc.creatorErs̈oz, G.en
dc.creatorFeyerabend, S.en
dc.creatorHinrichsen, H.en
dc.creatorManok, M.en
dc.creatorHäussinger, D.en
dc.creatorHerzog, W.en
dc.creatorHofmann, W. P.en
dc.creatorPlein, K.en
dc.creatorHardt, H.en
dc.creatorPorst, H.en
dc.creatorMederacke, I.en
dc.creatorRigopoulou, E. I.en
dc.creatorSentürk, H.en
dc.creatorWagner, E. K. V.en
dc.date.accessioned2015-11-23T10:30:39Z
dc.date.available2015-11-23T10:30:39Z
dc.date.issued2014
dc.identifier10.1111/liv.12376
dc.identifier.issn14783223
dc.identifier.urihttp://hdl.handle.net/11615/28667
dc.description.abstractBackground & Aims: Immunohistochemical assessment of liver tissue in chronic delta hepatitis (CDH) is underinvestigated. Aim of the study was (i) to assess variables associated with hepatitis D antigen (HDAg), hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) staining in the liver. Methods: Demographic, biochemical and virologic data collected from the HIDIT 1 study were used. HBsAg, HBcAg and HDAg immunohistochemical (IHC) staining was semiquantitatively assessed. Results: Hepatitis D antigen immunohistochemical staining displayed positive correlations with age and alanine aminotransferase (ALT) and negative correlations with serum HBsAg (P = 0.01 for all). HBsAg IHC displayed a negative correlation with gamma glutamyl transferase and positive correlations with serum HBV DNA, serum HBsAg levels and HBeAg serology (P < 0.001, P = 0.02 and P = 0.007 respectively). HBcAg staining was mainly nuclear and displayed negative correlations with serum HBsAg and histologic activity (P = 0.002 and P = 0.02 respectively). Pegylated IFN based treatment led to a decline of all IHC markers, however, these markers had no impact on treatment outcome. Conclusions: These data suggest an association of liver injury with HDAg expression in CDH whereas the negative correlation between HBcAg expression and liver injury and the overall nuclear localization of HBcAg suggest that HBcAg does not contribute to liver injury in CDH. HDV cases with high level of HBV replication, high serum HBsAg levels, HBeAg positivity, that are probably in the earlier stages of disease (low gamma-glutamyl transferase), had a more intense HBsAg staining profile. Overall, the data enforce the importance of HDAg and HBsAg in different phases of CDH infection. © 2013 John Wiley & Sons A/S.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84905722781&partnerID=40&md5=9d7b82b5c59b16b558c6500a61ca779f
dc.subjectChronic delta hepatitisen
dc.subjectDelta antigenen
dc.subjectHBcAgen
dc.subjectHBsAgen
dc.subjectImmunohistochemistryen
dc.subjectQuantitative surface antigenen
dc.subjectalanine aminotransferaseen
dc.subjectgamma glutamyltransferaseen
dc.subjecthepatitis B core antigenen
dc.subjecthepatitis B surface antigenen
dc.subjectvirus DNAen
dc.subjectbiological markeren
dc.subjecthepatitis delta antigenen
dc.subjectadolescenten
dc.subjectadulten
dc.subjectalanine aminotransferase blood levelen
dc.subjectantigen expressionen
dc.subjectarticleen
dc.subjectcell membraneen
dc.subjectcontrolled studyen
dc.subjectdelta agent hepatitisen
dc.subjectdisease markeren
dc.subjectenzyme immunoassayen
dc.subjectfemaleen
dc.subjectgamma glutamyl transferase blood levelen
dc.subjecthepatitis Ben
dc.subjectHepatitis B virusen
dc.subjectHepatitis delta virusen
dc.subjecthumanen
dc.subjecthuman tissueen
dc.subjectliveren
dc.subjectliver injuryen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectnonhumanen
dc.subjectprotein expressionen
dc.subjectserologyen
dc.subjecttreatment outcomeen
dc.subjectvirus loaden
dc.subjectageen
dc.subjectageden
dc.subjectblooden
dc.subjectclinical trialen
dc.subjectmetabolismen
dc.subjectmiddle ageden
dc.subjectmulticenter studyen
dc.subjectnonparametric testen
dc.subjectproceduresen
dc.subjectrandomized controlled trialen
dc.subjectreal time polymerase chain reactionen
dc.subjectvirologyen
dc.subjectAge Factorsen
dc.subjectAlanine Transaminaseen
dc.subjectBiological Markersen
dc.subjectgamma-Glutamyltransferaseen
dc.subjectHepatitis B Core Antigensen
dc.subjectHepatitis B Surface Antigensen
dc.subjectHepatitis D, Chronicen
dc.subjectHepatitis delta Antigensen
dc.subjectHumansen
dc.subjectReal-Time Polymerase Chain Reactionen
dc.subjectStatistics, Nonparametricen
dc.titleRole of immunohistochemistry for hepatitis D and hepatitis B virus in hepatitis deltaen
dc.typejournalArticleen


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