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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Does hepcidin affect erythropoiesis in hemodialysis patients?

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Author
Eleftheriadis, T.; Kartsios, C.; Liakopoulos, V.; Antoniadi, G.; Ditsa, M.; Papadopoulos, C.; Anifandis, G.; Skirta, A.; Markala, D.; Stefanidis, I.
Date
2006
DOI
10.1159/000095873
Keyword
Anemia
Hemodialysis
Hepcidin
Inflammation
Iron
C reactive protein
erythropoietin
ferric hydroxide sucrose
ferritin
recombinant erythropoietin
transferrin
transferrin receptor
adult
aged
article
blood level
blood sampling
clinical article
comparative study
controlled study
correlation analysis
enzyme linked immunosorbent assay
erythropoiesis
female
hematocrit
hemodialysis patient
human
iron blood level
iron deficiency
iron metabolism
male
multiple linear regression analysis
priority journal
Antimicrobial Cationic Peptides
Case-Control Studies
Humans
Linear Models
Middle Aged
Protein Precursors
Renal Dialysis
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Abstract
Introduction: Prohepcidin is the precursor of hepcidin, a liver-derived peptide involved in iron metabolism by blocking its intestinal absorption and its release by the reticuloendothelial system. Iron overload and inflammation increase hepcidin expression, whereas anemia and hypoxia suppress it. In the present study prohepcidin levels were determined in the serum of hemodialysis (HD) patients and its correlations with iron metabolism markers, C-reactive protein (CRP) and hematocrit (Hct) were assessed. Patients and Methods: Forty-sixHD patients and 22 healthy volunteers were enrolled in the study. Hct, serum prohepcidin, CRP, iron, ferritin, transferrin saturation and transferrin receptors were measured. The weekly erythropoietin dose, last-month intravenous iron dose and the patients' demographics were recorded. Results: In comparison to the healthy volunteers, the HD patients had higher serum ferritin, transferrin receptors and CRP, lower serum iron and similar transferrin saturation and prohepcidin levels. In the patient group prohepcidin levels were negatively correlated with Hct but not with any other of the examined parameters. Multiple linear regression analysis considering age, inflammation, iron adequacy, erythropoietin dose and prohepcidin levels revealed that prohepcidin was the predominant determinant of Hct. Conclusions: Taking into account the low Hct levels in the HD patients of our study, it seems plausible that the prohepcidin levels assessed in this group are inappropriately high. These functionally high prohepcidin levels may be associated with the factors that inhibit erythropoiesis in HD patients. On the other hand, the absence of other expected correlations indicates that further studies are needed in order to definitely clarify this aspect. Copyright © 2006 S. Karger AG.
URI
http://hdl.handle.net/11615/27314
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