In vivo evaluation of CUP1A2 and CYP2A6 activities in a Greek population during menopause

Abstract

Human CYP enzyme system is involved in the metabolism of various endogenous compounds. Previous studies have shown that CYP activity is influenced by age and gender. In the present study caffeine metabolites were used for the evaluation of CYP1A2 and CYP2A6 in vivo activities during menopause in a Greek population. Both enzymes were significantly smaller in post menopausal women suggesting that menopause affects CYP1A2 as well as CYP2A6 activities. ©PHARMAKON-Press.