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Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma
dc.creator | Abazis-Stamboulieh, D. | en |
dc.creator | Oikonomou, P. | en |
dc.creator | Papadoulis, N. | en |
dc.creator | Panayiotidis, P. | en |
dc.creator | Vrakidou, E. | en |
dc.creator | Tsezou, A. | en |
dc.date.accessioned | 2015-11-23T10:21:38Z | |
dc.date.available | 2015-11-23T10:21:38Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1080/10428190701615892 | |
dc.identifier.issn | 1042-8194 | |
dc.identifier.uri | http://hdl.handle.net/11615/25329 | |
dc.description.abstract | Interleukin-1 (IL-1) is a cytokine involved in the maturation and proliferation of B cells and plays a significant role in the development of lytic bone lesions, a major clinical feature of multiple myeloma (MM) patients. Genes that regulate products involved in the immune system are highly polymorphic and contribute to inter-individual differences that can influence the genetic predisposition and progression of particular diseases and cancers. In this study, we investigated the correlation between the single nucleotide polymorphisms IL1A -889, IL1B -511, IL1B +3954, IL1RN Mspa1 +11100 and susceptibility to MM in 74 patients and 160 controls. We found that individuals possessing IL1A -889 CT polymorphism had a higher risk in developing MM. Moreover, genotypes IL1B 7511 CC, IL1B +3954 CC, IL-1RN Mspa1 +11100 CC and the combination of IL 1B +3954 CC with IL1B 7511 CC or IL-1RN Mspa1 +11100 CC exerted a protective effect in individuals possessing them. | en |
dc.source | Leukemia & Lymphoma | en |
dc.source.uri | <Go to ISI>://WOS:000250839100019 | |
dc.subject | interleukin-1 | en |
dc.subject | polymorphisms | en |
dc.subject | multiple myeloma | en |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISMS | en |
dc.subject | NECROSIS-FACTOR-ALPHA | en |
dc.subject | BONE-MARROW | en |
dc.subject | CELLS | en |
dc.subject | CYTOKINE POLYMORPHISMS | en |
dc.subject | CANCER | en |
dc.subject | STIMULATION | en |
dc.subject | PROMOTER | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | POPULATION | en |
dc.subject | IL-1-BETA | en |
dc.subject | Oncology | en |
dc.subject | Hematology | en |
dc.title | Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma | en |
dc.type | journalArticle | en |
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