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Effect of Anti-Mullerian hormone (AMH) and bone morphogenetic protein 15 (BMP-15) on steroidogenesis in primary-cultured human luteinizing granulosa cells through Smad5 signalling
(2015)
To determine if there is any effect of AMH and BMP-15 on estradiol and progesterone production from primary-cultured human luteinizing granulosa cells, to delineate what is the effect of FSH on their actions and which are ...
The recombinant subdomain IIIB of human serum albumin displays activity of gonadotrophin surge-attenuating factor
(2004)
BACKGROUND: Gonadotrophin surge-attenuating factor (GnSAF) is an as yet unidentified ovarian factor that acts on the pituitary to attenuate the pre-ovulatory LH surge. In a previous study, GnSAF bioactivity was proposed ...
Leptin in human reproduction
(1999)
The recent discovery of the obese (ob) gene has provided new insight into the mechanism which controls body fat mass. Leptin, a product of the ob gene, serves as the link between fat and the brain. This protein, by acting ...
Polycystic ovaries and obesity
(2015)
Almost 50% of the women with polycystic ovary syndrome (PCOS) are obese. Obesity in PCOS affects reproduction via various mechanisms. Hyperandrogenism, increased luteinizing hormone (LH) and insulin resistance play a pivotal ...
Novel aspects of the endocrinology of the menstrual cycle
(2014)
Ovarian control of gonadotrophin secretion is normally achieved via the feedback mechanisms mediated by oestradiol and progesterone. Evidence has been provided that nonsteroidal substances, such as inhibin A and B, participate ...
Ovulation induction: a mini review
(2005)
Ovulation induction is the method for treating anovulatory infertility. For patients with hypogonadotrophic hypogonadism,the treatment involves administration of both FSH and LH, while HCG is injected for follicle rupture. ...
Modulatory effect of the ovary on LH secretion
(2003)
Ovarian steroids are important regulators of gonadotropin secretion during the normal menstrual cycle. Estradiol is the predominant factor in the follicular phase, while progesterone plays an important role in the luteal ...
Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women
(2010)
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E-2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical ...
Current and future status of ovulation induction in polycystic ovary syndrome
(1997)
Great progress has been achieved during the last 20 years in the field of ovulation induction in patients with polycystic ovary syndrome (PCOS). Clomiphene citrate remains the first line of treatment for all anovulatory ...
Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone
(2011)
Objectives: It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the ...