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The recombinant subdomain IIIB of human serum albumin displays activity of gonadotrophin surge-attenuating factor
(2004)
BACKGROUND: Gonadotrophin surge-attenuating factor (GnSAF) is an as yet unidentified ovarian factor that acts on the pituitary to attenuate the pre-ovulatory LH surge. In a previous study, GnSAF bioactivity was proposed ...
Polycystic ovaries and obesity
(2015)
Almost 50% of the women with polycystic ovary syndrome (PCOS) are obese. Obesity in PCOS affects reproduction via various mechanisms. Hyperandrogenism, increased luteinizing hormone (LH) and insulin resistance play a pivotal ...
Novel aspects of the endocrinology of the menstrual cycle
(2014)
Ovarian control of gonadotrophin secretion is normally achieved via the feedback mechanisms mediated by oestradiol and progesterone. Evidence has been provided that nonsteroidal substances, such as inhibin A and B, participate ...
Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women
(2010)
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E-2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical ...
Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone
(2011)
Objectives: It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the ...
Development and application of competitive ELISA assays for rat LH and FSH
(1999)
Rat LH (rLH) and FSH (rFSH) were measured by sensitive and specific competition ELISAs. The rat LH ELISA used rLH-I-9 coated plates, an antiserum against rLH and an antibody against rabbit IgG labeled with peroxidase. Using ...
FSH modulatory effect on human granulosa cells: a gene-protein candidate for gonadotrophin surge-attenuating factor
(2011)
Previous evidence indicates a homology of gonadotrophin surge-attenuating factor (GnSAF) to the carboxyl terminal of human serum albumin (HSA) and the ability of human granulosa cells to produce mRNA transcripts corresponding ...