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Novel aspects of the endocrinology of the menstrual cycle
(2014)
Ovarian control of gonadotrophin secretion is normally achieved via the feedback mechanisms mediated by oestradiol and progesterone. Evidence has been provided that nonsteroidal substances, such as inhibin A and B, participate ...
Ovulation induction: a mini review
(2005)
Ovulation induction is the method for treating anovulatory infertility. For patients with hypogonadotrophic hypogonadism,the treatment involves administration of both FSH and LH, while HCG is injected for follicle rupture. ...
Modulatory effect of the ovary on LH secretion
(2003)
Ovarian steroids are important regulators of gonadotropin secretion during the normal menstrual cycle. Estradiol is the predominant factor in the follicular phase, while progesterone plays an important role in the luteal ...
Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women
(2010)
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E-2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical ...
Current and future status of ovulation induction in polycystic ovary syndrome
(1997)
Great progress has been achieved during the last 20 years in the field of ovulation induction in patients with polycystic ovary syndrome (PCOS). Clomiphene citrate remains the first line of treatment for all anovulatory ...
Evidence of differential control of FSH and LH responses to GnRH by ovarian steroids in the luteal phase of the cycle
(2002)
BACKGROUND: It is known that during the follicular phase of the cycle, estradiol sensitizes the pituitary to GnRH. The aim of this study was to determine the role of ovarian steroids in the control of GnRH-induced gonadotrophin ...
The progesterone positive feedback effect in women after ovariectomy
(2013)
Various ovarian substances regulate the secretion of gonadotrophins during the menstrual cycle, but there are still several unclarified issues. The aim of this study was to investigate the positive feedback effect of ...
Ovarian feedback, mechanism of action and possible clinical implications
(2006)
The secretion of gonadotrophins from the pituitary in women is under ovarian control via negative and positive feedback mechanisms. Steroidal and non-steroidal substances mediate the ovarian effects on the hypothalamic-pituitary ...
Evidence that termination of the estradiol-induced luteinizing hormone surge in women is regulated by ovarian factors
(2006)
Background: The endogenous LH surge is the result of the estrogen-positive feedback effect. However, the factors that are responsible for the termination of LH surge are not known. Objective: The objective of the study was ...
From menarche to regular menstruation - Endocrinological background
(2006)
Marked changes in hormone secretion occur from childhood to adulthood. Prior to puberty gonadotropin-releasing hormone (GnRH) secretion is markedly suppressed. At the onset of puberty, the hypothalamic gonadostat is ...