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Novel aspects of the endocrinology of the menstrual cycle
(2014)
Ovarian control of gonadotrophin secretion is normally achieved via the feedback mechanisms mediated by oestradiol and progesterone. Evidence has been provided that nonsteroidal substances, such as inhibin A and B, participate ...
Ovulation induction: a mini review
(2005)
Ovulation induction is the method for treating anovulatory infertility. For patients with hypogonadotrophic hypogonadism,the treatment involves administration of both FSH and LH, while HCG is injected for follicle rupture. ...
Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women
(2010)
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E-2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical ...
Current and future status of ovulation induction in polycystic ovary syndrome
(1997)
Great progress has been achieved during the last 20 years in the field of ovulation induction in patients with polycystic ovary syndrome (PCOS). Clomiphene citrate remains the first line of treatment for all anovulatory ...
Evidence of differential control of FSH and LH responses to GnRH by ovarian steroids in the luteal phase of the cycle
(2002)
BACKGROUND: It is known that during the follicular phase of the cycle, estradiol sensitizes the pituitary to GnRH. The aim of this study was to determine the role of ovarian steroids in the control of GnRH-induced gonadotrophin ...
Ovarian feedback, mechanism of action and possible clinical implications
(2006)
The secretion of gonadotrophins from the pituitary in women is under ovarian control via negative and positive feedback mechanisms. Steroidal and non-steroidal substances mediate the ovarian effects on the hypothalamic-pituitary ...
Ghrelin: New Insights into Female Reproductive System-Associated Disorders and Pregnancy
(2012)
Ghrelin is considered the endogenous ligand of growth hormone secretagogue receptor type 1a, and its modulatory actions have been demonstrated in a large array of endocrine and nonendocrine functions. According to recent ...
Human ghrelin decreases pituitary response to GnRH in superovulated ewes
(2013)
In addition to its metabolic role, ghrelin has been found to suppress luteinizing hormone secretion in many species acting mainly at the hypothalamic level. The objectives of the present study were to test the hypothesis ...